{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:40:12Z","timestamp":1722332412424},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1095,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>Atypical                             perinuclear antineutrophil cytoplasmic antibodies (p\u2010ANCA)                             occur in most patients with ulcerative colitis but only                             in a minority of those with Crohn\u2032s disease. In a recent                             study from the United States, this serological marker                             was reported to be present in 100% of Crohn\u2032s disease                             patients with a clinical phenotype of \u2032left\u2010sided ulcerative                             colitis\u2032 but was not present in patients with \u2032isolated\u2032                             small bowel disease. In a previously reported survey                             from the author\u2032s hospital, the p\u2010ANCA status of 247                             consecutive patients with Crohn\u2032s disease was evaluated,                             and, of these, 33 Crohn\u2032s disease patients were seropositive,                             including 18 (13.0%) with combined small and large bowel                             disease, 11 (19.6%) with \u2032isolated\u2032 colorectal disease,                             and four (4.6%) with \u2032isolated\u2032 small bowel but no detectable                             colorectal disease. To further evaluate and verify the                             significance of atypical p\u2010ANCA in these 33 patients,                             clinical, radiological, endoscopic and histological                             features were examined. This study confirms that an                             \u2032ulcerative colitis\u2010like\u2032 clinical phenotype may be                             seen in most, but not all, serologically positive Crohn\u2032s                             disease patients. Moreover, \u2032isolated\u2032 small bowel disease                             in the absence of colorectal disease occurs. Detection                             of atypical p\u2010ANCA in Crohn\u2032s disease with different                             clinical and pathological features provides serological                             evidence that Crohn\u2032s disease is a very heterogeneous                             disorder.<\/jats:p>","DOI":"10.1155\/1997\/237085","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T21:19:53Z","timestamp":1459459193000},"page":"689-693","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies in Patients with Crohn\u2019s Disease"],"prefix":"10.1155","volume":"11","author":[{"given":"Hugh J","family":"Freeman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,12]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/1997\/237085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1997\/237085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:07:39Z","timestamp":1722330459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1997\/237085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1155\/1997\/237085"],"URL":"https:\/\/doi.org\/10.1155\/1997\/237085","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"type":"print","value":"2291-2789"},{"type":"electronic","value":"2291-2797"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"1997-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}