{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T17:10:44Z","timestamp":1722359444519},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1095,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Coordinating Office for Health Technology Assessment"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>Published                             data and techniques for decision analysis were used                             to construct a model to estimate the cost effectiveness                             of nine alternative strategies for the management of                             patients diagnosed with uncomplicated duodenal ulcer.                             Two strategies of intermittent therapy with either ranitidine                             or omeprazole, one strategy of continuous maintenance                             treatment with ranitidine, and six strategies for ulcer                             healing and eradication of <jats:italic>Helicobacter pylori<\/jats:italic>                             infection were considered. Healing time curves were                             estimated by using published data, allowing for estimation                             of expected time for acute healing episodes. The expected                             number of weeks to heal per patient, in a one\u2010year period,                             was estimated by combining healing time data with probability                             of ulcer recurrence. It was found that patients that                             underwent any of the six <jats:italic>H pylori<\/jats:italic> eradication                             regimens had fewer days with ulcer per year than those                             who underwent maintenance or intermittent ranitidine.                             Four eradication regimens had lower costs and better                             outcomes than ranitidine therapy. In comparing <jats:italic>H                             pylori<\/jats:italic> strategies, the two strategies of omeprazole                             plus one antibiotic (either amoxicillin or clarithromycin)                             are more costly than omeprazole plus two antibiotics                             (specifically amoxicillin and metronidazole or clarithromycin                             and metronidazole) and result in similar outcomes. Although                             omeprazole\u2010based eradication regimens are more costly                             than ranitidine bismuth triple therapy, they are associated                             with fewer recurrences of ulcer and days of symptoms.                             A limitation of the analysis is that it did not incorporate                             issues of compliance and metronidazole resistance; however,                             the former concern may be less of an issue as <jats:italic>H pylori<\/jats:italic>                             regimens become simpler and shorter in duration.<\/jats:p>","DOI":"10.1155\/1997\/290183","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T21:19:57Z","timestamp":1459459197000},"page":"323-331","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cost effectiveness of Alternative <i>Helicobacter pylori<\/i> Eradication Strategies in the Management of Duodenal Ulcer"],"prefix":"10.1155","volume":"11","author":[{"given":"Bernie","family":"O\u2032Brien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Goeree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"William","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,6]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/1997\/290183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1997\/290183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T16:53:58Z","timestamp":1722358438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1997\/290183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1155\/1997\/290183"],"URL":"https:\/\/doi.org\/10.1155\/1997\/290183","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"type":"print","value":"2291-2789"},{"type":"electronic","value":"2291-2797"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"1996-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}