{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T05:06:17Z","timestamp":1735707977224,"version":"3.32.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1188,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>OBJECTIVES: To compare the activity of piperacillin\u2010tazobactam with piperacillin and other parenterally administered antibiotics against aerobic Gram\u2010negative bacilli and Gram\u2010positive cocci isolated from across Canada, and to determine the prevalence of resistance mediated by extended\u2010spectrum cephalosporinases.<\/jats:p><jats:p>METHODS: Sixty\u2010one laboratories participated. Disk diffusion testing was performed in accordance with methods outlined by the National Committee for Clinical Laboratory Standards. Susceptibilities were performed on 8206 strains. <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Klebsiella pneumoniae<\/jats:italic> with reduced susceptibilities to third\u2010generation cephalosporins were screened for extended\u2010spectrum beta\u2010lactamases (ESBLs).<\/jats:p><jats:p>RESULTS: Piperacillin\u2010tazobactam was active against 92% of the strains, piperacillin against 81% and ticarcillin\u2010clavulanic acid against 88%. Few differences were observed in the relative susceptibility of strains from teaching or community hospitals, from different anatomic sites or from different regions of the country. Aerobic Gram\u2010negative bacilli tested tended to be more susceptible to all the agents than was recently reported in a similar American study. Only 43% of <jats:italic>Enterococcus faecium<\/jats:italic> were susceptible to ampicillin and 42% to piperacillin piperacillin with and without tazobactam. Only two enterococcal strains were resistant to vancomycin, and 19 had intermediate zone sizes. Of the 10 strains of <jats:italic>E coli<\/jats:italic> and eight strains of <jats:italic>K pneumoniae<\/jats:italic> with reduced susceptibility to extended spectrum cephalosporins, only one demonstrated typical ESBL activity.<\/jats:p><jats:p>CONCLUSIONS: Canadian aerobic Gram\u2010positive cocci and Gram\u2010negative bacilli remain highly susceptible to many currently available antibiotics. The findings confirm a broad spectrum of activity of piperacillin\u2010tazobactam and indicate that the pattern of susceptibility is quite uniform from different body sites, in both teaching and community hospitals, and across the country.<\/jats:p>","DOI":"10.1155\/1997\/632673","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T13:51:25Z","timestamp":1458049885000},"page":"147-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Study of the Comparative Activity of Piperacillin\/Tazobactam with Currently Available Antibiotics against 8206 Aerobic Isolates"],"prefix":"10.1155","volume":"8","author":[{"given":"Kevin R","family":"Forward","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald E","family":"Low","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Laverdiere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Rennie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E","family":"Simor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A","family":"Franks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Members of the Canadian Piperacillin\/Tazobactam Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,9,30]]},"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/1997\/632673.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1997\/632673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T05:02:15Z","timestamp":1735621335000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1997\/632673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9,30]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1155\/1997\/632673"],"URL":"https:\/\/doi.org\/10.1155\/1997\/632673","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"type":"print","value":"1712-9532"},{"type":"electronic","value":"1918-1493"}],"subject":[],"published":{"date-parts":[[1996,9,30]]},"assertion":[{"value":"1996-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}