{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:27:09Z","timestamp":1760264829314},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1117,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>It is widely accepted that the thymic microenvironment regulates normal thymopoiesis\nthrough a highly coordinated and complex series of cellular and cytokine interactions. A direct\ncorollary of this is that abnormalities within the microenvironment could be of etiologic\nsignificance in T\u2010cell\u2010based diseases. Our laboratory has developed a large panel of\nmonoclonal antibodies (mAbs) that react specifically with epithelial or nonepithelial\nmarkers in the thymus. We have taken advantage of these reagents to characterize the\nthymic microenvironment of several genetic strains of mice, including BALB\/cJ,\nC57BL\/6J, NZB\/BlnJ, SM\/J, NOD\/Ltz, NOD\/Ltz\u2010<jats:italic>scid\/sz<\/jats:italic>, C57BL\/6J\u2010<jats:italic>Hcph<\/jats:italic><jats:italic>m<\/jats:italic><jats:italic>e<\/jats:italic>\/<jats:italic>Hcph<\/jats:italic><jats:italic>m<\/jats:italic><jats:italic>e<\/jats:italic>, and\nALY\/NscJcl\u2010<jats:italic>aly\/aly<\/jats:italic> mice, and littermate control animals. We report herein that control\nmice, including strains of several backgrounds, have a very consistent phenotypic profile\nwith this panel of monoclonal antibodies, including reactivity with thymic epithelial cells\nin the cortex, the medulla and the corticomedullary junction, and the extracellular matrix.\nIn contrast, the disease\u2010prone strains studied have unique, abnormal staining of thymic cortex\nand medulla at both the structural and cellular levels. These phenotypic data suggest\nthat abnormalities in interactions between developing thymocytes and stromal cells characterize\ndisease\u2010prone mice.<\/jats:p>","DOI":"10.1155\/1997\/69270","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T07:54:53Z","timestamp":1213170893000},"page":"79-89","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Comparative Analysis of the Murine Thymic Microenvironment in Normal, Autoimmune, and Immunodeficiency States"],"prefix":"10.1155","volume":"5","author":[{"given":"Yuichi","family":"Takeoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Tsuneyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhisa","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Yago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seishi","family":"Suehiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aftab A.","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard D.","family":"Shultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,12,10]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/1997\/069270.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1997\/69270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T20:39:17Z","timestamp":1723063157000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1997\/69270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12,10]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1155\/1997\/69270"],"URL":"https:\/\/doi.org\/10.1155\/1997\/69270","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[1996,12,10]]},"assertion":[{"value":"1996-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}