{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T17:10:35Z","timestamp":1722359435256},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1095,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>Atypical                             perinuclear antineutrophil cytoplasmic antibodies (p\u2010ANCA)                             have been detected in most patients with ulcerative                             colitis and primary sclerosing cholangitis. Persistent                             atypical p\u2010ANCA have been observed in ulcerative colitis                             patients with a prior proctocolectomy, especially with                             pouchitis, suggesting that this serological marker might                             be predictive of subsequent development of chronic or                             refractory pouchitis. This study prospectively evaluated                             this serological marker in 24 consecutive patients with                             inflammatory bowel disease and prior colectomies (12                             with a clinical diagnosis of ulcerative colitis and                             12 with a clinical diagnosis of Crohn\u2032s disease involving                             the colon). Of these, 14 were positive, including 11                             with extensive ulcerative colitis and three with Crohn\u2032s                             disease. Although two of three ulcerative colitis patients                             with pouchitis were positive, eight of eight ulcerative                             colitis patients having a pelvic pouch with no pouchitis                             were also positive, as was a patient who elected to                             have an end\u2010ileostomy (Brooke\u2032s ileostomy). Two patients                             had abnormal liver chemistry tests. Both had end\u2010stage                             primary sclerosing cholangitis treated with liver transplantation                             and were positive for this serological marker. Although                             atypical p\u2010ANCA may be a marker of persistent inflammation                             in pelvic pouch patients, a positive test result should                             not be used for prognosis or as a decision\u2010making parameter                             for pelvic pouch procedures.<\/jats:p>","DOI":"10.1155\/1997\/765202","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T21:22:15Z","timestamp":1459459335000},"page":"305-310","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Atypical Perinuclear Antineutrophil Cytoplastmic Antibodies after Colectomy in Inflammatory Bowel Disease"],"prefix":"10.1155","volume":"11","author":[{"given":"Hugh J","family":"Freeman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Roeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana V","family":"Devine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric J","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,6]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/1997\/765202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1997\/765202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T16:54:03Z","timestamp":1722358443000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1997\/765202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1155\/1997\/765202"],"URL":"https:\/\/doi.org\/10.1155\/1997\/765202","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"type":"print","value":"2291-2789"},{"type":"electronic","value":"2291-2797"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"1996-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-11-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}