{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:28:29Z","timestamp":1779370109642,"version":"3.53.0"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1095,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>The                             objective of this study was to investigate the influence                             of food on the bioavailability of omeprazole (20 mg)                             given as an enteric\u2010coated tablet under repeated dose                             conditions. This open randomized crossover study consisted                             of three seven\u2010day treatment periods, each separated                             by a drug\u2010free period. During each treatment period                             an enteric\u2010coated tablet of omeprazole was taken once                             daily either under fasting conditions, or immediately                             before or after a standardized breakfast. On the last                             day of each treatment period, blood samples for the                             determination of plasma omeprazole concentrations were                             collected at baseline and at predetermined intervals                             over the 24 h period following drug administration.                             Fifty\u2010seven male and female subjects, aged 18 to 52                             years, completed the study according to the protocol.                             No statistically significant differences were found                             when comparing either the before breakfast or after                             breakfast treatment regimens with the fasting regimen                             for the estimated mean area under the plasma concentration\u2010time                             curve (AUC). The maximum plasma concentration was not                             found to differ significantly among any of the treatment                             regimens. However, the lower limit of the CI for the                             comparison of fasting\/before breakfast was not contained                             within the limits of bioequivalence. The time to reach                             maximum plasma concentration was significantly different                             when fasting and after breakfast regimens were compared.                             Thus, under repeated dose conditions, food has no influence                             on the bioavailability (expressed as AUC) of omeprazole                             given as the enteric\u2010coated tablet formulation.<\/jats:p>","DOI":"10.1155\/1997\/830856","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T21:23:03Z","timestamp":1459459383000},"page":"663-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Influence of Food on the Bioavailability of an Enteric\u2010Coated Tablet Formulation of Omeprazole 20 mg Under Repeated Dose Conditions"],"prefix":"10.1155","volume":"11","author":[{"given":"ABR","family":"Thomson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Matisko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Olofsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1997,12]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/1997\/830856.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1997\/830856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:07:36Z","timestamp":1722330456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1997\/830856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1155\/1997\/830856"],"URL":"https:\/\/doi.org\/10.1155\/1997\/830856","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"value":"2291-2789","type":"print"},{"value":"2291-2797","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"1997-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}