{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:40:10Z","timestamp":1722332410999},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1095,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>This                             study compared the 24 h intragastric pH profile and                             bioavailability at repeated dosing conditions of the                             omeprazole 20 mg enteric\u2010coated tablet versus the 20                             mg capsule. Forty duodenal ulcer patients in asymptomatic                             remission completed this randomized open two\u2010way crossover                             study. Omeprazole 20 mg tablets or capsules were administered                             for seven days in each period. A 24 h pH recording was                             performed before the start of treatment and on day 7                             of each treatment period. Plasma concentrations of omeprazole                             were determined 24 h after the dose. The treatment periods                             were separated by two to four weeks. The difference                             in percentage of time with pH of at least 3 was less                             than 16% in favour of the tablet (not significant).                             The estimated mean area under the plasma concentration\u2010time                             curve as well as the maximum plasma concentration (C<jats:sub>max<\/jats:sub>)                             for omeprazole were 18% and 41% higher, respectively,                             for the tablet versus the capsule, with the latter percentage                             being statistically significant. The time to reach C<jats:sub>max<\/jats:sub>                             (t<jats:sub>max<\/jats:sub>) with the tablet was, on average, about 0.5 h                             longer than to reach the t<jats:sub>max<\/jats:sub> of the capsule. This study                             indicates that the enteric\u2010coated tablet formulation                             of omeprazole is biodynamically equivalent to the capsule                             regarding their effects on intragastric pH during repeated                             dosing.<\/jats:p>","DOI":"10.1155\/1997\/910471","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T21:23:04Z","timestamp":1459459384000},"page":"657-660","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacokinetics and Pharmacodynamics during Treatment with the Omeprazole 20 mg Enteric\u2010Coated Tablet and 20 mg Capsule in Asymptomatic Duodenal Ulcer Patients"],"prefix":"10.1155","volume":"11","author":[{"given":"ABR","family":"Thomson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Kirdeikis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Lastiwka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Rohss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Olofsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,12]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/1997\/910471.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1997\/910471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:07:47Z","timestamp":1722330467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1997\/910471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1155\/1997\/910471"],"URL":"https:\/\/doi.org\/10.1155\/1997\/910471","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"type":"print","value":"2291-2789"},{"type":"electronic","value":"2291-2797"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"1997-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}