{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:59:22Z","timestamp":1769518762901,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1095,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>OBJECTIVE: To present a perspective on the current state of knowledge of cat scratch disease (CSD), including the evidence for <jats:italic>Bartonella henselae<\/jats:italic> as the etiological agent, epidemiological and clinical characteristics of the disease, available diagnostic tests and current therapeutic options.<\/jats:p><jats:p>DATA SOURCES: MEDLINE search of the literature published from 1966 to 1995 using \u2018cat scratch disease\u2019, \u2018Bartonella henselae\u2019, \u2018Rochalimaea henselae\u2019 as key words and bibliographies of selected papers.<\/jats:p><jats:p>DATA EXTRACTION: Selected studies reporting data on etiology, epidemiology, clinical characteristics, diagnosis and therapy of CSD were evaluated.<\/jats:p><jats:p>DATA SYNTHESIS AND CONCLUSIONS: Evidence accumulated to date supports <jats:italic>B henselae<\/jats:italic> as the etiological agent of CSD. The most significant risk factors for CSD are being licked on the face, scratched or bitten by a kitten and owning a kitten with fleas. Available serological tests can confirm classic CSD and identify <jats:italic>B henselae<\/jats:italic> as the cause of more atypical presentations, such as fever of unknown origin, granulomatous hepatitis, encephalitis and osteomyelitis. Symptomatic management is appropriate for isolated lymphadenopathy caused by CSD in healthy individuals; however, antibiotic therapy may be indicated for patients with more severe manifestations of the disease and immunocompromised hosts. Further study of CSD, in particular the epidemiology and therapy, is warranted. A better understanding of the pathogenesis of <jats:italic>B henselae<\/jats:italic> infection will have important implications in both immunocompetent and immunocompromised individuals.<\/jats:p>","DOI":"10.1155\/1997\/982908","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T08:09:35Z","timestamp":1458029375000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cat Scratch Disease: The Story Continues"],"prefix":"10.1155","volume":"8","author":[{"given":"Mary Anne","family":"Opavsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,1]]},"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/1997\/982908.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1997\/982908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T19:38:53Z","timestamp":1722368333000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1997\/982908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1155\/1997\/982908"],"URL":"https:\/\/doi.org\/10.1155\/1997\/982908","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"1997-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}