{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T10:40:13Z","timestamp":1723113613476},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":942,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HPB Surgery"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>In healthy subjects octreotide is largely metabolised\nby the liver suggesting that the plasma half\u2010life of the\nsomatostatin analogue may be prolonged in patients\nwith hepatic dysfunction. The aim of this study was\ntherefore (a) to determine the pharmacokinetics of\noctreotide following its subcutaneous injection in 6\npatients with cirrhosis and portal hypertension and\n(b) compare the magnitude and duration of the effects\nof intravenous administration of 250 \u03bcg somatostatin\nand 50 \u03bcg octreotide on corrected wedged hepatic\nvenous pressure (WHVP) and to relate the findings to\nthe plasma levels of the analogue 1h after administration\nin 13 patients with cirrhosis and portal\nhypertension. Following subcutaneous administration\nof 50 \u03bcg octreotide the circulating half life (range\n2.4 to 4.79 h) was prolonged whereas the clearance\n(range 2.101 to 4.775 L\/h) was decreased compared to\nhealthy controls. Intravenous bolus administration of\n25 \u03bcg somatostatin or 50 \u03bcg octreotide resulted in a\nreduction in WHVP of approximately the same\nmagnitude and duration despite appreciable quantities\nof the analogue in the blood lh after administration\n(1944 \u00b1 226 pg\/ml). These results indicate\nthat the circulating half\u2010life of octreotide is prolonged\nin cirrhotics suggesting that the dosage\nregimens should be modified in such patients to\navoid accumulation of the analogue in the blood\nwhich may result in undesirable side\u2010effects or\ntoxicity. Furthermore, since the magnitude and\nduration of the reduction in WHVP elicited by IV\noctreotide is similar to that obseved with somatostatin,\nthe analogue, like the native hormone, must be\nadministered by continuous IV infusion to produce a\nsustained response and hence a therapeutic effect in\nthe management of acute variceal bleeding.<\/jats:p>","DOI":"10.1155\/1998\/17436","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T09:19:26Z","timestamp":1189675166000},"page":"13-21","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pharmacokinetics of Octreotide in PatientsWith Cirrhosis and Portal Hypertension;Relationship Between the Plasma Levelsof the Analogue and the Magnitudeand Duration of the Reduction in CorrectedWedged Hepatic Venous Pressure"],"prefix":"10.1155","volume":"11","author":[{"given":"S. A.","family":"Jenkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Nott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. N.","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,6,3]]},"container-title":["HPB Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1998\/017436.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1998\/17436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T09:30:20Z","timestamp":1723109420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1998\/17436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6,3]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1155\/1998\/17436"],"URL":"https:\/\/doi.org\/10.1155\/1998\/17436","archive":["Portico"],"relation":{},"ISSN":["0894-8569","1607-8462"],"issn-type":[{"type":"print","value":"0894-8569"},{"type":"electronic","value":"1607-8462"}],"subject":[],"published":{"date-parts":[[1997,6,3]]},"assertion":[{"value":"1997-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}