{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:27:00Z","timestamp":1762100820236},"reference-count":0,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Mu 579\/3-2"],"award-info":[{"award-number":["Mu 579\/3-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>Low\u2010grade MALT\u2010type lymphomas are malignancies of mucosal marginal\u2010zone B cells\nand preceded by reactive inflammatory lymphoid tissue. Experimental observations suggest that antigen\nand CD40 Ligand act during cognate T\/B cell interaction and are crucial for germinal center B\u2010cell maturation\ngenerating marginal\u2010zone B cells. To investigate the mechanisms underlying the development of extranodal MALT\u2010type lymphomas, the immunoglobulin receptor was sequenced and analyzed for antigen specificity using heterohybridoma technology.\nFurthermore, CD40 ligand expression was evaluated by immunohistochemistry and by semiquantitative RT\u2010PCR,\nand ligand binding to the CD40 of tumor B cells was studied using the CD40 system. Hypermutations were found in low\u2010grade\nlymphomas throughout CDR1\u2010 CDR3 suggestive of positive selection through their antigen receptor.\nDifferent VH families were used and more than 69% of tumor immunoglobulins bound different mucosal antigens.\nCD40L expression was found in the tumor marginal zone in substantial amounts.\nThe <jats:italic>in vitro<\/jats:italic> proliferation response of all low\u2010grade MALT\u2010type lymphomas was dependent on\nanti\u2010CD40\u2010 mediated signals and cytokines. Our data provide evidence that autoantigen as well as the CD40L\nexpressed by activated nonneoplastic T cells may drive the evolution of low\u2010grade MALT\u2010type lymphomas either\ndirectly or by paracrine mechanisms and that antigen may contribute to lymphoma pathogenesis.<\/jats:p>","DOI":"10.1155\/1998\/18679","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T07:58:53Z","timestamp":1213171133000},"page":"187-196","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["CD40 Ligand and Autoantigen Are Involved in the Pathogenesis of Low\u2010Grade B\u2010Cell Lymphomas of Mucosa\u2010Associated Lymphoid Tissue"],"prefix":"10.1155","volume":"6","author":[{"given":"A.","family":"Greiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Kn\u00f6rr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Marx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Kroczek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. K.","family":"M\u00fcller-Hermelink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,1]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/1998\/018679.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1998\/18679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:39:40Z","timestamp":1723117180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1998\/18679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1155\/1998\/18679"],"URL":"https:\/\/doi.org\/10.1155\/1998\/18679","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[1998,1]]},"assertion":[{"value":"1996-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}