{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T06:23:48Z","timestamp":1743402228359},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":862,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI31972"],"award-info":[{"award-number":["AI31972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RPG-97-027"],"award-info":[{"award-number":["RPG-97-027"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>The role that interleukin\u20102 (IL\u20102) plays in T\u2010cell development is not known. To address this\nissue, we have investigated the nature of the abnormal thymic development and autoimmune\ndisorders that occurs in IL\u20102\u2010deficient (IL\u20102<jats:sup>\u2013\/\u2013<\/jats:sup>) mice. After 4 to 5 weeks of birth, IL\u20102<jats:sup>\u2013\/\u2013<\/jats:sup> mice\nprogressively develop a thymic disorder resulting in the disruption of thymocyte maturation.\nThis disorder is characterized by a dramatic reduction in cellularity, the selective loss of\nimmature CD4<jats:sup>-<\/jats:sup>8<jats:sup>-<\/jats:sup> (double negative; DN) and CD4<jats:sup>+<\/jats:sup>8<jats:sup>+<\/jats:sup> (double positive; DP) thymocytes and\ndefects in the thymic stromal\u2010cell compartment. Immunohistochemical staining of sections of\nthymuses from specific pathogen\u2010free and germ\u2010free IL\u20102<jats:sup>\u2013\/\u2013<\/jats:sup> mice of various ages showed a\nprogressive ,loss of cortical epithelial cells, MHC class II\u2010expressing cells, monocytes, and\nmacrophages. Reduced numbers of macrophages were apparent as early as week after birth.\nSince IL\u20102<jats:sup>\u2013\/\u2013<\/jats:sup> thymocyte progenitor populations could mature normally on transfer into a normal\nthymus, the thymic defect in IL\u20102<jats:sup>\u2013\/\u2013<\/jats:sup> mice appears to be due to abnormalities among thymic\nstromal cells. These results underscore the role of IL\u20102 in maintaining functional microenvironments\nthat are necessary to support thymocyte growth, development, and selection.<\/jats:p>","DOI":"10.1155\/1998\/19567","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T07:54:53Z","timestamp":1213170893000},"page":"287-302","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Thymic Stromal\u2010Cell Abnormalities and Dysregulated T\u2010Cell Development in IL\u20102\u2010Deficient Mice"],"prefix":"10.1155","volume":"5","author":[{"given":"Tannishtha","family":"Reya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Bassiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e","family":"Biancaniello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon R.","family":"Carding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,8,22]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/1998\/019567.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1998\/19567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:31:51Z","timestamp":1723116711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1998\/19567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8,22]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1155\/1998\/19567"],"URL":"https:\/\/doi.org\/10.1155\/1998\/19567","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[1997,8,22]]},"assertion":[{"value":"1997-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}