{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:00:22Z","timestamp":1761058822476},"reference-count":0,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":973,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>Mice with inactivated TNF\u2010LT<jats:italic>\u03b1<\/jats:italic> genes have profound abnormalities of the immune system with hypoimmunoglobulinaemia, lack of lymph nodes, undifferentiated spleen, and defective Ig class switch. Transplantation of bone marrow cells from wild\u2010type mice restored the synthesis of TNF, corrected the splenic microarchitecture, repopulated the lamina propria with IgA\u2010producing plasma cells, and normalized the serum immunoglobulin levels of TNF\u2010LT<jats:italic>\u03b1<\/jats:italic> deficient mice. Furthermore, the formation of germinal centers in the spleen and the defective Ig class switch in response to a T\u2010cell\u2010dependent antigen is corrected. These data demonstrate that most TNFproducing cells are bone\u2010marrow\u2010derived, and that the immunodeficiency due to TNF\u2010LT<jats:italic>\u03b1<\/jats:italic> deletion can be corrected to a large extent by normal bone marrow, cell transplantation.<\/jats:p>","DOI":"10.1155\/1998\/76963","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T07:58:53Z","timestamp":1213171133000},"page":"253-260","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Correction of the TNF\u2010LT<i>\u03b1<\/i>\u2010Deficient Phenotype by Bone Marrow Transplantation"],"prefix":"10.1155","volume":"6","author":[{"given":"Bernhard","family":"Ryffel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel Le","family":"Hir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Pietro","family":"Eugster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,5,3]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/1998\/076963.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/1998\/076963.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1998\/76963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:39:49Z","timestamp":1723117189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1998\/76963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5,3]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1155\/1998\/76963"],"URL":"https:\/\/doi.org\/10.1155\/1998\/76963","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[1997,5,3]]},"assertion":[{"value":"1996-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}