{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:54:25Z","timestamp":1761540865396},"reference-count":0,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":874,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Convention R\u00e9gion Wallonne, Universit\u00e9 de Li\u00e8ge","award":["2640"],"award-info":[{"award-number":["2640"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>The ability of human tonsillar lymphoid cells to express growth hormone receptor (hGH\u2010N\u2010R) was analyzed by flow cytometry. FITC\u2010coupled recombinant human growth hormone (hGH\u2010N) was used to reveal the receptors, in combination with phenotype markers.<\/jats:p><jats:p>Unlike T cells, tonsillar B cells constitutively express the hGH\u2010N receptor. Quiescent cells separated from activated cells by Percoll\u2010gradient centrifugation bear fewer receptors than activated ones. Activated T cells express hGH\u2010N\u2010R, but the typical germinal centre CD4<jats:sup>+<\/jats:sup>CD57<jats:sup>+<\/jats:sup> T cells do not. These latter thus appear not to be fully activated.<\/jats:p><jats:p>Inside the lymph follicles, the germinal centre CD38<jats:sup>+<\/jats:sup> B\u2010cell population and the mantle\u2010zone CD39<jats:sup>+<\/jats:sup> B\u2010cell population display similar levels of hGH\u2010N\u2010R expression, but receptor density is lower on dividing dark\u2010zone CD38<jats:sup>+<\/jats:sup>CD10<jats:sup>+<\/jats:sup> B cells.<\/jats:p><jats:p>Different lymphoid\u2010cell populations thus differ markedly in their ability to express the growth hormone receptor, in relation notably to their activation status. This highlights the link between the neuroendocrine system and the active immune defense.<\/jats:p>","DOI":"10.1155\/1998\/85209","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T07:58:53Z","timestamp":1213171133000},"page":"295-304","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Expression of Growth Hormone Receptors by Lymphocyte subpopulations in the Human tonsil"],"prefix":"10.1155","volume":"6","author":[{"given":"Olivier","family":"Thellin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Coumans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willy","family":"Zorzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Barnard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Hennen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Heinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Igout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,8,10]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/1998\/085209.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1998\/85209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:39:35Z","timestamp":1723117175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1998\/85209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8,10]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1155\/1998\/85209"],"URL":"https:\/\/doi.org\/10.1155\/1998\/85209","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[1997,8,10]]},"assertion":[{"value":"1996-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}