{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:40:01Z","timestamp":1723095601169},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":611,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HPB Surgery"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>Bleeding from portal hypertensive gastropathy\n(PHG) has been estimated to account for upto 30%\nof all upper gastrointestinal haemorrhage in patients\nwith cirrhosis and portal hypertension. Although\nportal hypertension seems to be an essential prerequisite,\nthe precise mechanisms responsible for\nthe development of PHG are unknown. The aim of\nthis study was to examine the role of injection sclerotherapy\nof oesophageal varices in the development\nof PHG. Gastric emptying was studied using a\nradionuclide test meal with the emptying characteristics\nof a slow liquid in 57 patients with cirrhosis\nand\/or portal hypertension (median age 53 yrs), of\nwhom 34 had received injection sclerotherapy for\ntheir oesophageal varices and 20 normal healthy\nvolunteers (median age 42 yrs). As vagal damage is\nassociated with more rapid emptying of liquids,\ndespite hold up of solids, this technique might be\nexpected to demonstrate such damage if gastric\nemptying was accelerated. The results indicated that\nthere was no difference in the rate of gastric\nemptying between normal healthy volunteers and\nportal hypertensive patients. However, patients who\nhad received injection sclerotherapy emptied their\nstomachs faster than those who had not (<jats:italic>p<\/jats:italic>&lt;0.05).\nFurthermore, the speed of gastric emptying correlated\ndirectly with the number of injections (<jats:italic>r<\/jats:italic>=0.41;\n<jats:italic>p<\/jats:italic>=0.02) and the volume of sclerosant injected\n(<jats:italic>r<\/jats:italic>=0.39; <jats:italic>p<\/jats:italic>=0.03). These observations suggest that\ninjection sclerotherapy for oesophageal varices\nresults in disturbances of gastric emptying that\nmay contribute to the pathogenesis of portal hypertensive\ngastropathy.<\/jats:p>","DOI":"10.1155\/1999\/27037","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T09:19:26Z","timestamp":1189675166000},"page":"141-150","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Do Alterations in the Rate of Gastric Emptyingafter Injection Sclerotherapy for OesophagealVarices Play any Role in the Developmentof Portal Hypertensive Gastropathy?"],"prefix":"10.1155","volume":"11","author":[{"given":"K. K.","family":"Balan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Grime","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Critchley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,4,30]]},"container-title":["HPB Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1999\/027037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1999\/27037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:22:48Z","timestamp":1723094568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1999\/27037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4,30]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.1155\/1999\/27037"],"URL":"https:\/\/doi.org\/10.1155\/1999\/27037","archive":["Portico"],"relation":{},"ISSN":["0894-8569","1607-8462"],"issn-type":[{"type":"print","value":"0894-8569"},{"type":"electronic","value":"1607-8462"}],"subject":[],"published":{"date-parts":[[1998,4,30]]},"assertion":[{"value":"1995-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}