{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T16:10:11Z","timestamp":1722355811830},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>OBJECTIVE: To describe the extent of the problem of multidrug\u2010resistant tuberculosis (MDR\u2010TB) in Alberta and British Columbia from 1989 to 1998.<\/jats:p><jats:p>DESIGN: A retrospective, population\u2010based descriptive study of all notified MDR\u2010TB cases in the context of all notified TB cases, all notified culture\u2010positive TB cases and all notified drug\u2010resistant TB cases.<\/jats:p><jats:p>SETTING: Provinces of Alberta and British Columbia, and their TB registries.<\/jats:p><jats:p>PATIENTS: All people with TB reported to the TB registries of Alberta and British Columbia between January 1, 1989 and June 30, 1998.<\/jats:p><jats:p>MAIN OUTCOME MEASURES: Drug susceptibility testing was performed in all cases of culture\u2010positive TB. Demographic, clinical and laboratory data on all cases of MDR\u2010TB were recorded.<\/jats:p><jats:p>RESULTS: Of 4606 notified cases of TB, 3553 (77.1%) were culture positive. Of these, 365 (10.3%) were drug resistant; of the drug\u2010resistant cases, 24 (6.6%) were MDR. Most MDR\u2010TB patients were foreign\u2010born; of the four Canadian\u2010born patients, two were infected while travelling abroad. Although foreign\u2010born patients were significantly more likely to harbour drug\u2010resistant strains, 14.3% versus 4.8%, respectively (P&lt;0.001), among those who were harbouring a drug\u2010resistant strain, the proportion of Canadian\u2010born versus foreign\u2010born patients with an MDR strain was the same (6.7% versus 6.6%, respectively). From 1994 to 1998 versus 1989 to 1993, the proportion of all drug\u2010resistant strains that were MDR was greater (9.0% versus 4.3%, respectively), but the difference was not statistically significant. Isolates from 16 of the 24 MDR\u2010TB cases had been archived. Each of these was fingerprinted and found to be unique. Most MDR\u2010TB cases (88%) were respiratory. Of those tested for human immunodeficiency virus (n=17), only one was seropositive. MDR\u2010TB was \u2018acquired\u2019 in 67% and \u2018primary\u2019 in 33% of cases. Eight (33%) of the MDR\u2010TB cases received curative courses of treatment, six (25%) are still being treated, and the remainder have either died (five, 21%), transferred out (four, 17%) or become \u2018chronic\u2019 (one, 4%). No secondary case of MDR\u2010TB has been identified in Alberta and British Columbia.<\/jats:p><jats:p>CONCLUSIONS: Most MDR\u2010TB in Alberta and British Columbia is imported. The proportion of all drug\u2010resistant cases that are MDR appears to be increasing, but not because of disease acquired from recent contact with MDR\u2010TB in Canada.<\/jats:p>","DOI":"10.1155\/1999\/456395","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T07:57:32Z","timestamp":1458028652000},"page":"155-160","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Multidrug\u2010Resistant Tuberculosis in Alberta and British Columbia, 1989 to 1998"],"prefix":"10.1155","volume":"6","author":[{"given":"Ahmed","family":"Hersi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Elwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Cowie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Kunimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,4,3]]},"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/1999\/456395.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1999\/456395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T15:36:40Z","timestamp":1722353800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1999\/456395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.1155\/1999\/456395"],"URL":"https:\/\/doi.org\/10.1155\/1999\/456395","archive":["Portico"],"relation":{},"ISSN":["1198-2241","1916-7245"],"issn-type":[{"type":"print","value":"1198-2241"},{"type":"electronic","value":"1916-7245"}],"subject":[],"published":{"date-parts":[[1999,1]]},"assertion":[{"value":"1999-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}