{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T15:40:06Z","timestamp":1722354006749},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>OBJECTIVE: To study the antimicrobial management of cancer patients with chemotherapy\u2010induced neutropenia by Canadian physicians.<\/jats:p><jats:p>SETTING: A cohort of 274 cancer patients with severe neutropenia (ie, less than 0.5\u00d710<jats:sup>9<\/jats:sup> neutrophils\/L) who participated in a prospective double\u2010blind, placebo controlled study on antifungal prophylaxis conducted in 14 Canadian university\u2010affiliated centres. Antifungal prophylaxis (oral fluconazole 400 mg daily) was administered to 153 of 274 (56%) patients.<\/jats:p><jats:p>RESULTS: Antibacterial prophylaxis with a quinolone was given to 87 patients (32%) at the onset of chemotherapy whereas trimethoprim\/sulphamethoxazole was given to 56 (20%) patients. Fever (ie, 38\u00b0C or over) occurred in 216 (79%) patients after a median duration of neutropenia of four days (range one to 31 days). Empirical antibacterial antibiotics were administered in 214 febrile patients. In 164 (77%) patients antibiotics were started during the first 24 h of fever. Monotherapy with a third generation cephalosporin and duotherapy with a antipseudomonal beta\u2010lactam and an aminoglycoside were prescribed in 69 (32%) and 61 (28%) of the febrile patients, respectively. Inclusion of vancomycin in the initial empirical regimen was noted in 32 (15%) patients. Modifications of the initial regimen occurred in 187 (87%) patients after a median of five days (range one to 28 days). Empirical systemic amphotericin B was added after a median duration of nine days (range one to 34 days) of the empirical antibacterial regimen.<\/jats:p><jats:p>CONCLUSIONS: Overall, the antimicrobial management of cancer patients with chemotherapy\u2010induced neutropenia by Canadian physicians follows the current guidelines promulgated by the Infectious Diseases Society of America.<\/jats:p>","DOI":"10.1155\/1999\/721790","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T08:03:25Z","timestamp":1458029005000},"page":"353-357","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antimicrobial Regimens Prescribed by Canadian Physicians for Chemotherapy\u2010Induced Febrile Neutropenic Episodes"],"prefix":"10.1155","volume":"10","author":[{"given":"Michel","family":"Laverdi\u00e8re","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J","family":"Bow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coleman","family":"Rotstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stratis","family":"Ioannou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Carr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narguess","family":"Moghaddam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"the Canadian Fluconazole Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,1,2]]},"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/1999\/721790.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1999\/721790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T15:02:46Z","timestamp":1722351766000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1999\/721790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.1155\/1999\/721790"],"URL":"https:\/\/doi.org\/10.1155\/1999\/721790","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"type":"print","value":"1712-9532"},{"type":"electronic","value":"1918-1493"}],"subject":[],"published":{"date-parts":[[1999,1]]},"assertion":[{"value":"1998-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}