{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:10:56Z","timestamp":1763057456925},"reference-count":0,"publisher":"Wiley","issue":"2-4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>The pathogenesis of chronic chagasic cardiomyophathy associated with Chagas disease is\nstill controversial, although evidence indicates a T cell\u2010dependent autoimmune process.\nUsing a mouse model for chronic Chagas disease, we previously evidenced that hearts grafted\nwithin the ears of Trypanosoma cruzi infected syngeneic recipients were rejected through a\nCD4<jats:sup>+<\/jats:sup> T cell\u2010dependent mechanism. Moreover, we showed that such a process was dependent\non laminin\u2010mediated interactions, since it could be abrogated by anti\u2010laminin or anti\u2010laminin\nreceptor antibodies. In this review the same passive cell transfer model is considered for discussion:\nthe participation of the laminin alteration in the composition of the inflammatory\ninfiltrate formed in response to the antimyocardial autoreactive CD4<jats:sup>+<\/jats:sup> T cells, as well as the\npresence of laminin\u2010binding cytokines. Finally we suggest the existence of a relationship\nbetween the inflammatory infiltrate, the laminin contents and deposition of pro\u2010inflammatory\nlaminin\u2010binding cytokines, which may act in concert during the generation of Chagas disease\u2010\nrelated cardiomyophathy.<\/jats:p>","DOI":"10.1155\/2000\/17424","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T08:03:14Z","timestamp":1213171394000},"page":"293-301","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Involvement of Laminin in Anti\u2010Myocardial CellAutoimmune Response in Murine Chagas Disease"],"prefix":"10.1155","volume":"7","author":[{"given":"Suse Dayse","family":"Silva-Barbosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson","family":"Savino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,1]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2000\/017424.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2000\/17424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:30:32Z","timestamp":1723116632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2000\/17424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"2-4","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/2000\/17424"],"URL":"https:\/\/doi.org\/10.1155\/2000\/17424","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"2000-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}