{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:34:52Z","timestamp":1762176892784},"reference-count":0,"publisher":"Wiley","issue":"D","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":319,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>In\ncirrhosis of the liver, according to the peripheral arterial vasodilation\nhypothesis, relative underfilling of the arterial tree triggers a\nneurohumoral response (activation of renin\u2010angiotensinaldosterone\nsystem, sympathetic nervous system, nonosmotic release\nof vasopressin) aimed at restoring circulatory integrity by\npromoting renal sodium and water retention. Evidence has accumulated\nfor a major role of increased vascular production of nitric\noxide as the primary cause of arterial vasodilation in cirrhosis. Ascites\nis a common complication in cirrhosis. Treatment of ascites\nconsists of a low salt diet with diuretics, and paracentesis together\nwith plasma volume expanders in diuretic\u2010resistant patients. Progression\nof cirrhosis may result in hepatorenal syndrome, a state of\nfunctional renal failure that carries an ominous prognosis. Orthotopic\nliver transplantation has remained the only curative treatment\nfor patients with advanced liver disease; other modalities\nsuch as transjugular intrahepatic portosystemic shunt or vasopressin\nanalogues may serve as a bridge to transplantation. Another\ncomplication of decompensated cirrhosis is spontaneous\nbacterial peritonitis, the incidence of which can be reduced by primary\nor secondary antibiotic prophylaxis by using orally active antibiotics.<\/jats:p>","DOI":"10.1155\/2000\/340128","type":"journal-article","created":{"date-parts":[[2016,5,15]],"date-time":"2016-05-15T21:00:44Z","timestamp":1463346044000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Update on Peripheral Arterial Vasodilation, Ascites and Hepatorenal Syndrome in Cirrhosis"],"prefix":"10.1155","volume":"14","author":[{"given":"Mladen","family":"Knotek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Rogachev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W","family":"Schrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,2,16]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/340128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2000\/340128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:13:33Z","timestamp":1722521613000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2000\/340128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2,16]]},"references-count":0,"journal-issue":{"issue":"D","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/2000\/340128"],"URL":"https:\/\/doi.org\/10.1155\/2000\/340128","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"type":"print","value":"2291-2789"},{"type":"electronic","value":"2291-2797"}],"subject":[],"published":{"date-parts":[[1999,2,16]]},"assertion":[{"value":"1999-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-02-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}