{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T01:20:50Z","timestamp":1700270450280},"reference-count":0,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Programa de Promoci\u00f3n de la Investigaci\u00f3n en Salud del Ministerio de Sanidad y Consumo","award":["97\/1300"],"award-info":[{"award-number":["97\/1300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>BACKGROUND: Prostaglandin E<jats:sub>1<\/jats:sub>(PGE<jats:sub>1<\/jats:sub>) treatment of humans and rodents during acute hepatic failure ameliorates different parameters of hepatic dysfunction.<\/jats:p><jats:p>PURPOSE: To investigate whether prevention of acute liver injury induced by D-galactosamine (D-GalN) with preadministration of PGE<jats:sub>1<\/jats:sub>is correlated with a change in the concentration of two proinflammatory cytokines, as tumour necrosis factor-alpha (TNF-\u03b1) and interleukin (IL)-1\u03b1, and\/or nitrite+nitrate (NOx), as nitric oxide-related end products in serum.<\/jats:p><jats:p>RESULTS: D-GalN significantly increased alanine aminotransferase (ALT) and TNF- \u03b1concentration in serum 5 and 10 mins, respectively, after treatment compared with the control group (P&amp;#8804;0.05). D-GalN did not change the IL-1\u03b1 concentration at any time during the study. Preadministration of PGE<jats:sub>1<\/jats:sub>to D-GalN-treated rats significantly reduced the ALT content and increased significantly the TNF-\u03b1 concentration in serum 1, 2.5, 5 and 10\u00a0mins after D-GalN treatment compared with the D-GalN group (P&amp;#8804;0.05). Nitric oxide was not involved in either the toxic effect due to D-GalN or the protection observed with PGE<jats:sub>1<\/jats:sub>against D-GalN toxicity.<\/jats:p><jats:p>CONCLUSIONS: Acute liver injury induced by D-GalN is correlated with an increased TNF-\u03b1 release. Preadministration of PGE<jats:sub>1<\/jats:sub>to D-GalN-treated rats exerted a priming effect on inflammatory cells to release enhanced levels of TNF-\u03b1 but not IL-1\u03b1. These findings indicate that stimulation of TNF-\u03b1 release may be involved in the acute D-GalN-induced liver injury and also in PGE<jats:sub>1<\/jats:sub>protection from hepatotoxicity in clinical and experimental studies.<\/jats:p>","DOI":"10.1155\/2000\/416705","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T12:56:57Z","timestamp":1460638617000},"page":"175-180","source":"Crossref","is-referenced-by-count":13,"title":["TNF-alpha but not IL-1alpha are Correlated with PGE<sub>1<\/sub>-Dependent Protection Against Acute D-Galactosamine-Induced Liver Injury"],"prefix":"10.1155","volume":"14","author":[{"given":"J","family":"Muntan\u00e9","sequence":"first","affiliation":[{"name":"Servicio Aparato Digestivo, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JL","family":"Montero","sequence":"additional","affiliation":[{"name":"Servicio Aparato Digestivo, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JM","family":"Lozano","sequence":"additional","affiliation":[{"name":"Servicio Aparato Digestivo, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Miranda-Vizuete","sequence":"additional","affiliation":[{"name":"Servicio Aparato Digestivo, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"de la Mata","sequence":"additional","affiliation":[{"name":"Servicio Aparato Digestivo, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Mi\u00f1o","sequence":"additional","affiliation":[{"name":"Servicio Aparato Digestivo, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/416705.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/416705.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T05:10:54Z","timestamp":1471929054000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2000\/416705\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000]]}},"alternative-id":["416705"],"URL":"https:\/\/doi.org\/10.1155\/2000\/416705","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2000]]}}}