{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:54:50Z","timestamp":1760100890353},"reference-count":0,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>In-depth meetings of the XIth International Workshop on Gastroduodenal Pathology and<jats:italic>Helicobacter pylori<\/jats:italic>led to the presentation and discussion of extensive new data on<jats:italic>H pylori<\/jats:italic>and its diseases. The mode of transmission of<jats:italic>H pylori<\/jats:italic>remains unclear, and it remains unknown why only a small proportion of infected individuals develop duodenal or gastric ulcer disease and even fewer develop gastric cancer. The role of<jats:italic>H pylori<\/jats:italic>eradication in persons with uninvestigated dyspepsia remains controversial. New clinical trials of<jats:italic>H pylori<\/jats:italic>treatment show symptom relief and improvement in the quality of life of persons with functional dyspepsia, especially in those with ulcer-like or reflux-like dyspepsia. Clearly the move is toward symptom-based management of persons with dyspepsia, with fewer endoscopies being needed in the otherwise healthy young dyspeptic patients. It remains controversial whether eradicating<jats:italic>H pylori<\/jats:italic>in duodenal ulcer or functional dyspepsia increases the risk of subsequent development of gastroesophageal reflux disease. The one-week proton pump inhibitor-based triple regimens remain the gold standard of<jats:italic>H pylori<\/jats:italic>therapy, but some of the ranitidine bismuth citrate plus two antibiotic regimens also achieve an 80%<jats:italic>H pylori<\/jats:italic>eradication rate on an intention-to-treat basis. While the urea breath test remains the noninvasive test of choice, interesting new data are available on the use of stool antigen testing to diagnose<jats:italic>H pylori<\/jats:italic>infection. The number of<jats:italic>H pylori<\/jats:italic>-associated gastroduodenal diseases grows to include possible liver, vascular, immune and skin conditions.<\/jats:p>","DOI":"10.1155\/2000\/578059","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T16:57:13Z","timestamp":1460653033000},"page":"188-198","source":"Crossref","is-referenced-by-count":7,"title":["From Bench to Bedside to Bug: An Update of Clinically Relevant Advances in the Care of Persons with<i>Helicobacter pylori<\/i>Associated Diseases"],"prefix":"10.1155","volume":"14","author":[{"given":"N","family":"Chiba","sequence":"first","affiliation":[{"name":"Surrey GI Clinic, Guelph, Ontario and Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ABR","family":"Thomson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Sinclair","sequence":"additional","affiliation":[{"name":"AstraZeneca Canada Inc, Mississauga, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/578059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/578059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T12:36:02Z","timestamp":1471955762000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2000\/578059\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000]]}},"alternative-id":["578059"],"URL":"https:\/\/doi.org\/10.1155\/2000\/578059","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2000]]}}}