{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:01:45Z","timestamp":1780437705275,"version":"3.54.1"},"reference-count":0,"publisher":"Wiley","issue":"D","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":346,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>Moderate thrombocytopenia\nis a frequent finding in cirrhosis of the liver and well\ntolerated in most instances. The pathophysiology of thrombocytopenia\nin liver disease has long been associated with the concept\nof hypersplenism, where portal hypertension was thought to cause\npooling and sequestration of all corpuscular elements of the blood,\npredominantly thrombocytes in the enlarged spleen. The concept of\nhypersplenism was never proven beyond any doubt but was widely\naccepted for the lack of alternative explanations.<\/jats:p><jats:p>With the discovery of the lineage\u2010specific cytokine thrombopoietin\n(TPO) the missing link between hepatocellular function\nand thrombopoiesis was found. TPO is predominantly produced\nby the liver and constitutively expressed by hepatocytes.TPOproduction\nin humans is dependent on functional liver cell mass and\nis reduced when liver cell mass is severely damaged. This leads to\nreduced thrombopoiesis in the bone marrow and consequently to\nthrombocytopenia in the peripheral blood of patients with\nadvanced\u2010stage liver disease.<\/jats:p><jats:p>With recombinant TPOs in development, patients with liver disease\nand TPO seem to be the ideal target population for this drug.\nOnce the efficacy of thrombopoietin in patients with liver disease\nis proven, a potent yet safe drug may be available to treat cirrhotic\npatients undergoing invasive or surgical procedures, during bleeding\nepisodes or when undergoing therapy with myelosuppressive\ndrugs such as interferon\u2010alpha.<\/jats:p>","DOI":"10.1155\/2000\/617428","type":"journal-article","created":{"date-parts":[[2016,5,15]],"date-time":"2016-05-15T21:00:57Z","timestamp":1463346057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Thrombocytopenia in Liver Disease"],"prefix":"10.1155","volume":"14","author":[{"given":"Markus","family":"Peck-Radosavljevic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1999,1,20]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/617428.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2000\/617428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:13:25Z","timestamp":1722521605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2000\/617428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1,20]]},"references-count":0,"journal-issue":{"issue":"D","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/2000\/617428"],"URL":"https:\/\/doi.org\/10.1155\/2000\/617428","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"value":"2291-2789","type":"print"},{"value":"2291-2797","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1,20]]},"assertion":[{"value":"1999-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}