{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:15:26Z","timestamp":1770956126202,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"D","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":330,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>Neonatal jaundice may indicate cholestasis rather\nthan a benign, physiological condition. Any four\u2010week\u2010old newborn\nwith persistent jaundice should have a fractionated bilirubin\nscreen to determine whether the hyperbilirubinemia is unconjugated.\nConjugated hyperbilirubinemia, a hallmark of neonatal\ncholestasis, is pathological and requires further investigation.\nThese infants need prompt diagnosis, early intervention and careful\nfollow\u2010up to ensure continued growth and development. Recent\nprogress in the physiology of bile flow is reviewed, and the\nevaluation and management of neonatal cholestasis are summarized.\nFurther advances in delineating the cellular and molecular\nprocesses that regulate bile acid metabolism in both health and\ndisease will lead to a greater understanding of the conditions causing\nneonatal cholestasis. Unravelling the etiopathogenesis of\nthese neonatal cholestatic disorders will allow the development of\nnovel diagnostic and therapeutic interventions that ultimately\nwill effectuate the prognosis for these young patients.<\/jats:p>","DOI":"10.1155\/2000\/657368","type":"journal-article","created":{"date-parts":[[2016,5,15]],"date-time":"2016-05-15T21:00:53Z","timestamp":1463346053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neonatal Cholestasis: A Red Alert for the Jaundiced Newborn"],"prefix":"10.1155","volume":"14","author":[{"given":"Dinesh","family":"Pashankar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,2,5]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/657368.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2000\/657368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:13:04Z","timestamp":1722521584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2000\/657368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2,5]]},"references-count":0,"journal-issue":{"issue":"D","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/2000\/657368"],"URL":"https:\/\/doi.org\/10.1155\/2000\/657368","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"value":"2291-2789","type":"print"},{"value":"2291-2797","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2,5]]},"assertion":[{"value":"1999-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-02-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}