{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:30:19Z","timestamp":1761291019081},"reference-count":0,"publisher":"Wiley","issue":"D","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":207,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>The clinical course of an episode\nof acute pancreatitis varies from a mild, transitory form to a\nsevere necrotizing form characterized by multisystem organ failure\nand mortality in 20% to 40% of cases. Mild pancreatitis does\nnot need specialized treatment, and surgery is necessary only to\ntreat underlying mechanical factors such as gallstones or tumours\nat the papilla of Vater. On the other hand, patients with severe\nnecrotizing pancreatitis need to be identified as early as possible\nafter the onset of symptoms to start intensive care treatment. In\nthis subgroup of patients, approximately 15% to 20% of all patients\nwith acute pancreatitis, stratification according to infection\nstatus is crucial. Patients with infected necrosis must\nundergo surgical intervention, which consists of an organpreserving\nnecrosectomy followed by postoperative lavage\nand\/or drainage to evacuate necrotic debris, which appears during\nthe further course of the condition. Primary intensive care\ntreatment, including antibiotic treatment, delays the need for\nsurgery in most patients until the third or fourth week after the\nonset of symptoms. At that time, necrosectomy is technically\neasier to perform and the bleeding risk is reduced, compared with\nnecrosectomy earlier in the disease course. In patients with sterile\nnecrosis, the available data strongly support a conservative\napproach (ie, intensive care unit treatment). Surgery is rarely\nnecessary in these patients.<\/jats:p>","DOI":"10.1155\/2000\/710910","type":"journal-article","created":{"date-parts":[[2016,5,15]],"date-time":"2016-05-15T21:01:14Z","timestamp":1463346074000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Role of Surgery in the Management of Acute Pancreatitis"],"prefix":"10.1155","volume":"14","author":[{"given":"Beat","family":"Gloor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemar","family":"Uhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe A","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus W","family":"B\u00fcchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,6,8]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/710910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2000\/710910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:13:18Z","timestamp":1722521598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2000\/710910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6,8]]},"references-count":0,"journal-issue":{"issue":"D","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/2000\/710910"],"URL":"https:\/\/doi.org\/10.1155\/2000\/710910","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"type":"print","value":"2291-2789"},{"type":"electronic","value":"2291-2797"}],"subject":[],"published":{"date-parts":[[1999,6,8]]},"assertion":[{"value":"1999-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}