{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:35:18Z","timestamp":1761129318587},"reference-count":0,"publisher":"Hindawi Limited","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>A 29-year-old man with Crohn\u2019s disease involving the ileum and cecum was seen. He had angioneurotic edema with C-1\u2019 esterase inhibitor deficiency. Later, his 50-year-old mother was evaluated because of abdominal pain. She had recurrent urticaria, C-1\u2019 esterase inhibitor deficiency and radiographic studies showed Crohn\u2019s disease of the ileum. A maternal family history revealed other members affected with either Crohn\u2019s disease or angioneurotic edema. The clinical observations in this family suggest that angioneurotic edema associated with C-1\u2019 esterase inhibitor deficiency may be closely linked genetically with a familial form of Crohn\u2019s disease.<\/jats:p>","DOI":"10.1155\/2000\/828679","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T12:57:45Z","timestamp":1460638665000},"page":"337-339","source":"Crossref","is-referenced-by-count":9,"title":["Hereditary Angioneurotic Edema and Familial Crohn\u2019s Disease"],"prefix":"10.1155","volume":"14","author":[{"given":"Hugh J","family":"Freeman","sequence":"first","affiliation":[{"name":"Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/828679.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/828679.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T11:04:17Z","timestamp":1471950257000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2000\/828679\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000]]}},"alternative-id":["828679"],"URL":"https:\/\/doi.org\/10.1155\/2000\/828679","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2000]]}}}