{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:40:03Z","timestamp":1722523203228},"reference-count":0,"publisher":"Wiley","issue":"D","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":202,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>The purpose of the present review is to discuss the diagnosis\nand management of cholestatic liver diseases. Differential diagnoses\nto consider are described, including causes of extrahepatic\nbiliary obstruction such as gallstones, strictures, extrabiliary malignancies\nand pancreatitis. In addition, diseases that cause intrahepatic\ncholestasis such as primary biliary cirrhosis, primary\nsclerosing cholangitis, hepatocellular diseases and a variety of miscellaneous\ncauses including drugs that may cause cholestasis are\ndiscussed. Primary biliary cirrhosis and primary sclerosing\ncholangitis are reviewed in detail, and management options are\nidentified. The prognosis of patients with these diseases is discussed,\nand the Mayo Mathematical Models in Cholestatic Liver\nDisease for both primary biliary cirrhosis and primary sclerosing\ncholangitis are provided. Finally, management options for the\ncomplications of cholestasis are provided.<\/jats:p>","DOI":"10.1155\/2000\/871543","type":"journal-article","created":{"date-parts":[[2016,5,15]],"date-time":"2016-05-15T21:01:19Z","timestamp":1463346079000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Medical Management of Chronic Cholestatic Liver Diseases"],"prefix":"10.1155","volume":"14","author":[{"given":"Andrea A","family":"Gossard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith D","family":"Lindor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,6,13]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/871543.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2000\/871543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:12:58Z","timestamp":1722521578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2000\/871543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6,13]]},"references-count":0,"journal-issue":{"issue":"D","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/2000\/871543"],"URL":"https:\/\/doi.org\/10.1155\/2000\/871543","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"type":"print","value":"2291-2789"},{"type":"electronic","value":"2291-2797"}],"subject":[],"published":{"date-parts":[[1999,6,13]]},"assertion":[{"value":"1999-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-06-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}