{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T08:28:25Z","timestamp":1724142505225},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>The relation between estrogen receptors (ER) and argyrophilic nucleolar organizer regions (AgNORs) <jats:italic>in situ<\/jats:italic> within human breast cancer cells was analyzed. For AgNOR measurements in 49 invasive breast carcinomas, a new reproducible staining method for dual demonstration of ER and AgNORs was applied. Quantitative AgNOR variables were determined in ER\u2010positive and ER\u2010negative tumor cells by digital image analysis. The relationships between AgNOR parameters of ER\u2010positive and ER\u2010negative cells and other prognostic factors of breast cancer [Bloom\u2013Richardson\u2010Grading and growth fraction (Ki\u201067 index)] were investigated. A higher AgNOR content in ER\u2010negative cells and a special clustering phenomenon in ER\u2010positive tumor cells were found. Correlation with other criteria of malignant potential could be exclusively demonstrated for ER\u2010negative cells. ER\u2010negative cells of breast cancer can be characterized as the more malignant and possibly prognosis\u2010dictating cell fraction. Thus, ER\u2010negative cells probably contribute more to the progression of the tumor disease and furthermore to the prognosis than ER\u2010positive cells. We recommend measurement AgNORs exclusively in ER\u2010negative cells of breast cancer.<\/jats:p>","DOI":"10.1155\/2000\/914765","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T14:17:01Z","timestamp":1421072221000},"page":"155-162","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Different Proliferation Patterns in Breast Cancer: AgNOR Measurements in ER\u2010Negative and ER\u2010Positive Tumor Cells"],"prefix":"10.1155","volume":"20","author":[{"given":"Lukas","family":"G\u00fcnther","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hufnagl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus\u2010J\u00fcrgen","family":"Winzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Guski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,9,11]]},"container-title":["Analytical Cellular Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/acp\/2000\/914765.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2000\/914765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T13:21:03Z","timestamp":1722345663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2000\/914765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/2000\/914765"],"URL":"https:\/\/doi.org\/10.1155\/2000\/914765","archive":["Portico"],"relation":{},"ISSN":["2210-7177","2210-7185"],"issn-type":[{"type":"print","value":"2210-7177"},{"type":"electronic","value":"2210-7185"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"1999-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}