{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:32:16Z","timestamp":1759530736808},"reference-count":0,"publisher":"Wiley","issue":"D","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":207,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>A\nmild to moderate iron excess is found in patients with liver diseases\napparently unrelated to genetic hemochromatosis. Iron appears to\naffect the natural history of hepatitis C virus\u2010related chronic liver\ndiseases, alcoholic liver disease and nonalcoholic steatohepatitis\nby leading to a more severe fibrosis and thus aiding the evolution\nto cirrhosis.Ahigher frequency of mutations of the HFE gene, the\ngene responsible for hereditary hemochromatosis, is found in patients\nwith liver diseases and increased liver iron than in normal\npatients. Patients with excess iron are potentially at a higher risk\nof developing hepatocellular carcinoma. Iron depletion therapy\ncould interfere with fibrosis development and possibly reduce the\nrisk of liver cancer occurrence.<\/jats:p>","DOI":"10.1155\/2000\/954802","type":"journal-article","created":{"date-parts":[[2016,5,15]],"date-time":"2016-05-15T21:01:21Z","timestamp":1463346081000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Iron and Liver Diseases"],"prefix":"10.1155","volume":"14","author":[{"given":"Silvia","family":"Fargion","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Mattioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Ludovica","family":"Fracanzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemino","family":"Fiorelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,6,8]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2000\/954802.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2000\/954802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:13:23Z","timestamp":1722521603000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2000\/954802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6,8]]},"references-count":0,"journal-issue":{"issue":"D","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1155\/2000\/954802"],"URL":"https:\/\/doi.org\/10.1155\/2000\/954802","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"type":"print","value":"2291-2789"},{"type":"electronic","value":"2291-2797"}],"subject":[],"published":{"date-parts":[[1999,6,8]]},"assertion":[{"value":"1999-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}