{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:05:14Z","timestamp":1740135914735,"version":"3.37.3"},"reference-count":0,"publisher":"Wiley","issue":"1-4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100010443","name":"University of Illinois","doi-asserted-by":"publisher","award":["N65236-98-1-5409"],"award-info":[{"award-number":["N65236-98-1-5409"]}],"id":[{"id":"10.13039\/100010443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["VLSI Design"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>This paper discusses the use of established Technology Computer\u2010Aided Design\n(TCAD) tools and methodologies for the study of charge transport in molecular biology\nsystems, like ionic channels, that display a behavior analogous to electronic devices.\nContinuum drift\u2010diffusion and Monte Carlo methods can be applied to analyze steady\u2010state\nand transient behavior of ionic channels over time scales that cannot be resolved\npractically by detailed molecular dynamics or quantum approaches. The difficult ion\u2010water\ninteraction can be lumped phenomenologically into mobility or scattering rate\nparameters, while the solution of Poisson equation over the complete domain provides a\nsimple way to include external boundary conditions and image force effects at dielectric\ndiscontinuities. We present here some recent results of 3\u2010D simulations for a gramicidin\nion channel, obtained using the rapid prototyping computational platform PROPHET.<\/jats:p>","DOI":"10.1155\/2001\/25603","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T13:00:57Z","timestamp":1190120457000},"page":"179-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Simulation of Biological Ionic Channels by TechnologyComputer\u2010Aided Design"],"prefix":"10.1155","volume":"13","author":[{"given":"K.","family":"Hess","sequence":"first","affiliation":[]},{"given":"U.","family":"Ravaioli","sequence":"additional","affiliation":[]},{"given":"M.","family":"Gupta","sequence":"additional","affiliation":[]},{"given":"N.","family":"Aluru","sequence":"additional","affiliation":[]},{"family":"van der Straaten","sequence":"additional","affiliation":[]},{"given":"R. S.","family":"Eisenberg","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,1]]},"container-title":["VLSI Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2001\/025603.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2001\/25603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T13:35:05Z","timestamp":1723210505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2001\/25603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":0,"journal-issue":{"issue":"1-4","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1155\/2001\/25603"],"URL":"https:\/\/doi.org\/10.1155\/2001\/25603","archive":["Portico"],"relation":{},"ISSN":["1065-514X","1563-5171"],"issn-type":[{"type":"print","value":"1065-514X"},{"type":"electronic","value":"1563-5171"}],"subject":[],"published":{"date-parts":[[2001,1]]},"assertion":[{"value":"2001-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}