{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:08:58Z","timestamp":1765609738771},"reference-count":0,"publisher":"Wiley","issue":"B","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>There is considerable interest in the mechanisms\nthat underlie symptom generation in irritable bowel syndrome\n(IBS) and particularly those mechanisms peripheral to higher\ncentres in the nervous system. While the central nervous system\nis important in IBS, it is restricted largely to the role of behaviour\nin stress perception and symptom reporting. The gut and\nthe autonomic nervous system are principal areas of research in\nidentifying mechanisms underlying symptom generation and in\nthe identification of new targets for drug development. While\nmotility changes occur in IBS, they are neither specific nor predictable,\nand this is one reason why drugs aimed at influencing\nmotility patterns have enjoyed limited success to date. This success\nhas prompted interest in sensory physiology to explain pain\nand other discomforts expressed by patients with IBS. Patients\nwith IBS exhibit intolerance to rectal distension and other\nmanoeuvres of the gut, while exhibiting normal or raised thresholds\nfor somatic pain. The mechanisms underlying the development\nof hyperalgesia or allodynia in the gut remain to be\ndetermined. In other systems and experimental models, low\ngrade inflammation is a predicable inducer of these states, and\nrecent evidence suggests that a subpopulation of patients with\nIBS develop chronic symptoms after acute gastroenteritis. This\nand other inflammatory stimuli may induce a hyperalgesic state\nand alter motor function in patients with IBS. Substances that\nmediate these changes are not fully understood, but there is\ngrowing recognition of the role of serotonin as a sensitizing\nagent.<\/jats:p>","DOI":"10.1155\/2001\/690794","type":"journal-article","created":{"date-parts":[[2016,5,15]],"date-time":"2016-05-15T21:01:06Z","timestamp":1463346066000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Peripheral Mechanisms of Symptom Generation in Irritable Bowel Syndrome"],"prefix":"10.1155","volume":"15","author":[{"given":"Stephen M","family":"Collins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,1]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2001\/690794.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2001\/690794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:20:10Z","timestamp":1722522010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2001\/690794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":0,"journal-issue":{"issue":"B","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1155\/2001\/690794"],"URL":"https:\/\/doi.org\/10.1155\/2001\/690794","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"type":"print","value":"2291-2789"},{"type":"electronic","value":"2291-2797"}],"subject":[],"published":{"date-parts":[[2001,1]]},"assertion":[{"value":"2001-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}