{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:49:15Z","timestamp":1789004955177,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR46255-02"],"award-info":[{"award-number":["R01 AR46255-02"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["2R44-HL-61057-02"],"award-info":[{"award-number":["2R44-HL-61057-02"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006370","name":"Small Business Innovation Research","doi-asserted-by":"publisher","award":["R01 AR46255-02"],"award-info":[{"award-number":["R01 AR46255-02"]}],"id":[{"id":"10.13039\/100006370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006370","name":"Small Business Innovation Research","doi-asserted-by":"publisher","award":["2R44-HL-61057-02"],"award-info":[{"award-number":["2R44-HL-61057-02"]}],"id":[{"id":"10.13039\/100006370","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Whitaker Foundation for Biomedical Engineering","award":["R01 AR46255-02"],"award-info":[{"award-number":["R01 AR46255-02"]}]},{"name":"Whitaker Foundation for Biomedical Engineering","award":["2R44-HL-61057-02"],"award-info":[{"award-number":["2R44-HL-61057-02"]}]},{"name":"New York City Council Speaker\u2019s Fund for Biomedical Research","award":["R01 AR46255-02"],"award-info":[{"award-number":["R01 AR46255-02"]}]},{"name":"New York City Council Speaker\u2019s Fund for Biomedical Research","award":["2R44-HL-61057-02"],"award-info":[{"award-number":["2R44-HL-61057-02"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>Diffuse optical tomography (DOT) is emerging as a viable new biomedical imaging modality. Using near\u2010infrared (NIR) light, this technique probes absorption as well as scattering properties of biological tissues. First commercial instruments are now available that allow users to obtain cross\u2010sectional and volumetric views of various body parts. Currently, the main applications are brain, breast, limb, joint, and fluorescence\/bioluminescence imaging. Although the spatial resolution is limited when compared with other imaging modalities, such as magnetic resonance imaging (MRI) or X\u2010ray computerized tomography (CT), DOT provides access to a variety of physiological parameters that otherwise are not accessible, including sub\u2010second imaging of hemodynamics and other fast\u2010changing processes. Furthermore, DOT can be realized in compact, portable instrumentation that allows for bedside monitoring at relatively low cost. In this paper, we present an overview of current state\u2010of\u2010the \u2010art technology, including hardware and image\u2010reconstruction algorithms, and focus on applications in brain and joint imaging. In addition, we present recent results of work on optical tomographic imaging in small animals.<\/jats:p>","DOI":"10.1155\/2002\/164252","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T11:28:02Z","timestamp":1371122882000},"page":"313-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Near\u2010Infrared Diffuse Optical Tomography"],"prefix":"10.1155","volume":"18","author":[{"given":"A. H.","family":"Hielscher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Y.","family":"Bluestone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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