{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:55:59Z","timestamp":1777377359132,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>BACKGROUND: Distal ulcerative colitis usually responds to treatment with rectal mesalamine, but the management of refractory cases is poorly defined.<\/jats:p><jats:p>AIM: To evaluate the possible therapeutic benefit of transdermal nicotine versus oral mesalamine.<\/jats:p><jats:p>PATIENTS AND METHODS: Thirty patients with left-sided ulcerative colitis unresponsive to treatment with a mesalamine 4\u2009g enema at bedtime were randomly allocated to additional therapy with either transdermal nicotine 15\u2009mg daily or oral mesalamine 800\u2009mg tid for four weeks. Clinical remission was evaluated by Rachmilewitz\u2019s activity index and confirmed by sigmoidoscopy.<\/jats:p><jats:p>RESULTS: Remission was observed in 12 of 15 patients receiving additional treatment with nicotine and in five of 15 patients receiving additional treatment with oral mesalamine (P=0.027).<\/jats:p><jats:p>CONCLUSIONS: The addition of transdermal nicotine to treatment with mesalamine enemas is significantly superior to combined therapy with oral and rectal mesalamine in patients with distal ulcerative colitis refractory to rectal mesalamine alone.<\/jats:p>","DOI":"10.1155\/2002\/307218","type":"journal-article","created":{"date-parts":[[2016,3,20]],"date-time":"2016-03-20T21:01:03Z","timestamp":1458507663000},"page":"293-296","source":"Crossref","is-referenced-by-count":33,"title":["Distal Ulcerative Colitis Refractory to Rectal Mesalamine: Role of Transdermal Nicotine versus Oral Mesalamine"],"prefix":"10.1155","volume":"16","author":[{"given":"Mario","family":"Guslandi","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, San Raffaele University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Frego","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, San Raffaele University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edi","family":"Viale","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, San Raffaele University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Alberto","family":"Testoni","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, San Raffaele University Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2002\/307218.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2002\/307218.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T08:16:28Z","timestamp":1471940188000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2002\/307218\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002]]}},"alternative-id":["307218"],"URL":"https:\/\/doi.org\/10.1155\/2002\/307218","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2002]]}}}