{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T09:07:49Z","timestamp":1648631269575},"reference-count":0,"publisher":"Hindawi Limited","issue":"9","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>There are several reasons for eradicating <jats:italic>Helicobacter pylori<\/jats:italic> in  patients with chronic gastroesophageal reflux disease (GERD).  Perhaps the most compelling is the evidence that chronic acid  suppression therapy can lead to the development of atrophic gastritis,  a premalignant condition, in patients with <jats:italic>H pylori<\/jats:italic> infection.  Epidemiological data that suggest that <jats:italic>H pylori<\/jats:italic> is less  prevalent in GERD patients than in control subjects may be susceptible  to publication bias, and confounding social and environmental  factors may also be involved. Although it has been  thought that eradication of the organism might lead to increased  esophageal acid exposure, this has not been demonstrated in  practice. Studies that appeared to show that GERD could be provoked  by antimicrobial therapy of duodenal ulcers also have  methodological weaknesses. Underlying GERD symptoms might  be unmasked after withdrawal of acid-suppression therapy, for  reasons that are unrelated to <jats:italic>H pylori<\/jats:italic>. In fact, eradication of the  organism has been shown to decrease heartburn in patients with  peptic ulcer disease. When <jats:italic>H pylori<\/jats:italic> is successfully eradicated in  patients with GERD, relapse rates are not increased, and the disease-  free interval seems to be prolonged. Eradication of the  organism is a wise policy in patients who face long term acid-suppression  therapy for GERD.<\/jats:p>","DOI":"10.1155\/2002\/576957","type":"journal-article","created":{"date-parts":[[2016,3,20]],"date-time":"2016-03-20T21:01:40Z","timestamp":1458507700000},"page":"611-614","source":"Crossref","is-referenced-by-count":3,"title":["Motion \u2013 <i>Helicobacter pylori<\/i> Causes or Worsens GERD: Arguments for the Motion"],"prefix":"10.1155","volume":"16","author":[{"given":"Colm A","family":"O\u2019Morain","sequence":"first","affiliation":[{"name":"Adelaide and Meath Hospital, Trinity College, Tallaght, Dublin 24, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asghar","family":"Qasim","sequence":"additional","affiliation":[{"name":"Adelaide and Meath Hospital, Trinity College, Tallaght, Dublin 24, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2002\/576957.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2002\/576957.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T21:03:39Z","timestamp":1486587819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cjgh\/2002\/576957\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002]]}},"alternative-id":["576957"],"URL":"https:\/\/doi.org\/10.1155\/2002\/576957","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2002]]}}}