{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:30:21Z","timestamp":1789075821149,"version":"build-2803163510"},"reference-count":0,"publisher":"Hindawi Limited","issue":"8","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>BACKGROUND: Several reports have shown the prevalence of anti-CagA antibodies to be associated with the development of peptic ulcer diseases, while others have indicated that there is no such association.<\/jats:p><jats:p>AIM: To examine the prevalence of antibodies to CagA and other<jats:italic>Helicobacter pylori<\/jats:italic>antigens in symptomatic and asymptomatic subjects in Turkey.<\/jats:p><jats:p>SUBJECTS AND METHODS: Sixty-six symptomatic subjects, 16 to 74 years of age, were examined for<jats:italic>H pylori<\/jats:italic>by biopsy-based tests and ELISA. One hundred nineteen asymptomatic subjects, 20 to 65 years of age, were also tested serologically for the presence of<jats:italic>H pylori<\/jats:italic>. Samples from both groups that were found to be positive for<jats:italic>H pylori<\/jats:italic>by ELISA were then tested by immunoblotting.<\/jats:p><jats:p>RESULTS: Fifty-four (82%) symptomatic subjects and 76 (64%) asymptomatic subjects were found to be<jats:italic>H pylori<\/jats:italic>-positive by ELISA. Samples from 30 symptomatic subjects who were found to be<jats:italic>H pylori<\/jats:italic>-positive by ELISA were analyzed by immunoblotting. Antibodies to CagA (116 kDa) antigen were detected in immunoblots of 11 of 14 (79%) with chronic gastritis, 12 of 13 (92%) with duodenal ulcer and three of three (100%) with gastric cancer. Antigens of the following molecular weights were also detected in these 30 subjects: 89 kDa (VacA) in 21 (70%), 37 kDa in 21 (70%), 35 kDa in 19 (63%), 30 kDa in 27 (90%) and 19.5 kDa in 19 (63%). Immunoblots of 40 ELISA-positive asymptomatic subjects showed that 33 (83%) had antibodies to CagA antigen, 26 (65%) to VacA antigen, 30 (75%) to a 37 kDa antigen, 30 (75%) to a 35 kDa antigen, 39 (98%) to a 30 kDa antigen and 36 (90%) to a 19.5 kDa antigen.<\/jats:p><jats:p>CONCLUSIONS: Antibodies to CagA antigen were prevalent in both groups, regardless of the presence of gastroduodenal disease.<\/jats:p>","DOI":"10.1155\/2002\/589087","type":"journal-article","created":{"date-parts":[[2016,3,20]],"date-time":"2016-03-20T21:01:27Z","timestamp":1458507687000},"page":"527-532","source":"Crossref","is-referenced-by-count":14,"title":["<i>Helicobacter pylori<\/i>Anti-CagA Antibodies: Prevalence in Symptomatic and Asymptomatic Subjects in Turkey"],"prefix":"10.1155","volume":"16","author":[{"given":"M Fatih","family":"Abasiyanik","sequence":"first","affiliation":[{"name":"Fatih University, Faculty of Science and Literature, Department of Biology\/Microbiology Unit, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersan","family":"Sander","sequence":"additional","affiliation":[{"name":"Samatya Hospital, Gastroenterology Department\/Endoscopy Unit, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barik A","family":"Salih","sequence":"additional","affiliation":[{"name":"Fatih University, Faculty of Science and Literature, Department of Biology\/Microbiology Unit, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2002\/589087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2002\/589087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T11:26:25Z","timestamp":1471951585000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2002\/589087\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002]]}},"alternative-id":["589087"],"URL":"https:\/\/doi.org\/10.1155\/2002\/589087","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2002]]}}}