{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:27:32Z","timestamp":1785806852394,"version":"3.56.0"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009014","name":"Abbott Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008207","name":"AstraZeneca Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008207","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Axcan Pharma Inc"},{"name":"Glaxo Wellcome"},{"name":"Solvay Pharma\/BYK Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>Dyspepsia describes a symptom complex thought to arise in the upper gastrointestinal tract and includes, in addition to epigastric pain or discomfort, symptoms such as heartburn, acid regurgitation, excessive burping or belching, a feeling of slow digestion, early satiety, nausea and bloating. Based on the evidence that heartburn cannot be reliably distinguished from other dyspeptic symptoms, the Rome definition appears to be too narrow and restrictive. It is particularly ill suited to the management of uninvestigated dyspepsia at the level of primary care. In patients presenting with uninvestigated dyspepsia, a symptom benefit is associated with a \u2018test and treat\u2019 approach for<jats:italic>Helicobacter pylori<\/jats:italic>infection. A substantial proportion of those who do not benefit prove to have esophagitis on endoscopy. In those with functional dyspepsia, the benefits of<jats:italic>H pylori<\/jats:italic>eradication, if any, appear to be modest. Hence, a \"symptom and treat\" acid-suppression trial with proton pump inhibitors, and a \u2018test and treat\u2019 strategy for<jats:italic>H pylori<\/jats:italic>are two acceptable empirical therapies for patients with univestigated dyspepsia.<\/jats:p>","DOI":"10.1155\/2002\/679683","type":"journal-article","created":{"date-parts":[[2016,3,20]],"date-time":"2016-03-20T17:01:52Z","timestamp":1458493312000},"page":"635-641","source":"Crossref","is-referenced-by-count":14,"title":["Etiology of Dyspepsia: Implication for Empiric Therapy"],"prefix":"10.1155","volume":"16","author":[{"given":"Richard H","family":"Hunt","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Fallone","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander Veldhuyzen","family":"van Zanten","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Sherman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Flook","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Smaill","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan BR","family":"Thomson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"the Canadian Helicobacter Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2002\/679683.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2002\/679683.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T09:27:18Z","timestamp":1471944438000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2002\/679683\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002]]}},"alternative-id":["679683"],"URL":"https:\/\/doi.org\/10.1155\/2002\/679683","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2002]]}}}