{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:55:43Z","timestamp":1773154543077,"version":"3.50.1"},"reference-count":0,"publisher":"Hindawi Limited","issue":"2","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Infectious Diseases"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>OBJECTIVE: To evaluate the epidemiological evidence for an etiological role of Epstein-Barr virus in multiple sclerosis (MS).<\/jats:p><jats:p>DATA SOURCES: MEDLINE and Cochrane Library searches of the medical literature identified 24 studies.<\/jats:p><jats:p>DATA EXTRACTION: Studies were categorized as seroepidemiological, case-control or historical cohort, and were then classified within each group according to methodological rigour using criteria derived from published guidelines for the epidemiological study of MS.<\/jats:p><jats:p>DATA SYNTHESIS: There was significant variability in the quality of evidence, and while two well-designed cohort studies found increased relative risks of MS in subjects with infectious mononucleosis, results from other studies were unconvincing.<\/jats:p><jats:p>CONCLUSIONS: The evidence was insufficient to accept or reject the hypothesis that Epstein-Barr virus has an etiological role in MS. Further study, ideally using large samples of incident cases with blinded, trained interviewers using confirmatory sources for recalled data, is needed.<\/jats:p>","DOI":"10.1155\/2002\/745764","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T08:04:08Z","timestamp":1458029048000},"page":"111-118","source":"Crossref","is-referenced-by-count":9,"title":["Multiple Sclerosis and Epstein-Barr Virus"],"prefix":"10.1155","volume":"13","author":[{"given":"Ruth Ann","family":"Marrie","sequence":"first","affiliation":[{"name":"Montreal Neurological Institute, McGill University, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Wolfson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, McGill University, and Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2002\/745764.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2002\/745764.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T14:43:30Z","timestamp":1471963410000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjidmm\/2002\/745764\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002]]}},"alternative-id":["745764"],"URL":"https:\/\/doi.org\/10.1155\/2002\/745764","relation":{},"ISSN":["1180-2332"],"issn-type":[{"value":"1180-2332","type":"print"}],"subject":[],"published":{"date-parts":[[2002]]}}}