{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:08:26Z","timestamp":1765609706934},"reference-count":0,"publisher":"Hindawi Limited","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>Mutations of two genes, the cystic fibrosis transmembrane conductance regulator gene (<jats:italic>CFTR<\/jats:italic>) and the pancreatic secretory trypsin inhibitor gene (<jats:italic>PSTI<\/jats:italic>), are associated with an increase in the risk of idiopathic chronic pancreatitis. Persons who have mutations of both<jats:italic>CFTR<\/jats:italic>alleles (one severely and one mildly affected) are especially susceptible to this disease. Because these compound heterozygotes have sufficient residual<jats:italic>CFTR<\/jats:italic>function, they do not develop cystic fibrosis lung disease. One<jats:italic>PSTI<\/jats:italic>mutation, N34S, independently increases the risk of pancreatitis. Thus, the risk of pancreatitis is greatest among individuals who are<jats:italic>CFTR<\/jats:italic>compound heterozygotes and who also have the<jats:italic>PSTI<\/jats:italic>mutation. Nonetheless, most people with<jats:italic>CFTR<\/jats:italic>and<jats:italic>PSTI<\/jats:italic>mutations do not develop pancreatitis. This fact indicates that environmental influences and gene-gene interactions also affect pancreatitis risk. Although<jats:italic>CFTR<\/jats:italic>and<jats:italic>PSTI<\/jats:italic>genetic testing can identify persons at an increased risk of pancreatitis, there are several reasons why the routine screening of individuals with nonhereditary pancreatitis is not recommended at this time: most disease-associated mutations are not detected by readily available techniques, genetic counselling guidelines do not exist, most patients with mutations do not develop pancreatitis and the results of testing do not affect the clinical management of pancreatitis.<\/jats:p>","DOI":"10.1155\/2003\/169280","type":"journal-article","created":{"date-parts":[[2016,3,20]],"date-time":"2016-03-20T21:00:54Z","timestamp":1458507654000},"page":"53-55","source":"Crossref","is-referenced-by-count":9,"title":["Motion-Genetic Testing is Useful in the Diagnosis of Nonhereditary Pancreatic Conditions: Arguments Against the Motion"],"prefix":"10.1155","volume":"17","author":[{"given":"Jonathan A","family":"Cohn","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Duke University Medical Center, Durham North Carolina 27710-001, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2003\/169280.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2003\/169280.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T07:40:49Z","timestamp":1471938049000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2003\/169280\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003]]}},"alternative-id":["169280"],"URL":"https:\/\/doi.org\/10.1155\/2003\/169280","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2003]]}}}