{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:40:03Z","timestamp":1722523203230},"reference-count":0,"publisher":"Wiley","issue":"B","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p>The most commonly used regimen for <jats:italic>Helicobacter pylori<\/jats:italic> therapy at\npresent is twice\u2010daily proton pump inhibitor (PPI)\u2010based triple therapy.\nBismuth\u2010based therapy is the next most common treatment used\nby gastroenterologists. When a PPI is combined with bismuth\u2010based\ntriple therapy (quadruple therapy), eradication rates are increased as\ncompared with the triple therapy alone. Three separate randomized\ntrials from three continents that compare quadruple therapy and PPIbased\ntriple therapy revealed remarkably similar results. Eradication\nrates with PPI\u2010based triple therapy and quadruple therapy were not\nsignificantly different. The eradication rates with quadruple therapy\nwere 3% to 6% higher than PPI triple therapy, indicating that\nquadruple therapy should be no less effective than PPI triple therapy.\nFurthermore, these two therapies had similar rates of compliance and\nadverse events.<\/jats:p><jats:p>The major potential benefit of the quadruple therapy relates to\nantibiotic resistance. In patients with clarithromycin resistance, PPIbased\ntriple therapy, but not quadruple therapy, had a significantly\nlower eradication rate. However, due to its ability to largely overcome\nmetronidazole resistance, quadruple therapy had little if any decrement\nin eradication rates compared with PPI triple therapy in\npatients with metronidazole\u2010resistant <jats:italic>H pylori<\/jats:italic>. Therefore, quadruple\ntherapy can be considered a first line therapy for <jats:italic>H pylori<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2003\/303528","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T21:01:04Z","timestamp":1463432464000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Is It Time for Quadruple Therapy to be First Line?"],"prefix":"10.1155","volume":"17","author":[{"given":"Loren","family":"Laine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,1]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2003\/303528.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2003\/303528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:14:33Z","timestamp":1722521673000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2003\/303528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":0,"journal-issue":{"issue":"B","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1155\/2003\/303528"],"URL":"https:\/\/doi.org\/10.1155\/2003\/303528","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"type":"print","value":"2291-2789"},{"type":"electronic","value":"2291-2797"}],"subject":[],"published":{"date-parts":[[2003,1]]},"assertion":[{"value":"2003-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}