{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:41:32Z","timestamp":1791297692129,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"B","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p><jats:italic>Helicobacter pylori<\/jats:italic> infects half of the world\u2019s population, and is associated\nwith asymptomatic gastritis and also with more serious conditions\nsuch as peptic ulcer disease and gastric carcinoma. The clinical\noutcome is largely dependent on the severity and distribution of the\n<jats:italic>H pylori<\/jats:italic>\u2010induced gastritis, but the pathogenesis remains poorly understood.\nBacterial virulence factors and environmental influences contribute\nto the pathogenesis, but do not explain the divergent\noutcomes. There is emerging evidence that host genetic factors play\na key role in determining the clinical outcome of <jats:italic>H pylori<\/jats:italic> infection.\nIn particular, proinflammatory genotypes of the interleukin\u20101 beta\n(IL\u20101\u03b2) gene are associated with an increased risk of gastric cancer\nand its precursors. The effects are most likely mediated through the\ninduction of hypochlorhydria and severe corpus gastritis with the\nsubsequent development of gastric atrophy. The roles of IL\u20101\u03b2 and\nother host genetic factors in the pathogenesis of <jats:italic>H pylori<\/jats:italic> related cancer\nare discussed in this article.<\/jats:p>","DOI":"10.1155\/2003\/397060","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T21:01:13Z","timestamp":1463432473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Role of Interleukin\u20101Beta and Other Potential Genetic Markers as Indicators of Gastric Cancer Risk"],"prefix":"10.1155","volume":"17","author":[{"given":"Esther","family":"Troost","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina L","family":"Hold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm G","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wong-Ho","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S","family":"Rbkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth EL","family":"McColl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad M","family":"El-Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,1]]},"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2003\/397060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2003\/397060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T14:14:44Z","timestamp":1722521684000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2003\/397060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":0,"journal-issue":{"issue":"B","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1155\/2003\/397060"],"URL":"https:\/\/doi.org\/10.1155\/2003\/397060","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"value":"2291-2789","type":"print"},{"value":"2291-2797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]},"assertion":[{"value":"2003-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}