{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:31:02Z","timestamp":1776893462162,"version":"3.51.2"},"reference-count":0,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>BACKGROUND: Irritable bowel syndrome (IBS) is the most common functional bowel disorder and has a strong predominance in women. Recent data suggest that the brain may play an important role in the pathophysiology of IBS in the brain-gut axis. It is strongly suspected that serotonin (5-HT), a neurotransmitter found in the brain and gut, may be related to the pathophysiology of IBS. It is reported that a 5-HT<jats:sub>3<\/jats:sub>antagonist is effective only in female patients with diarrhea-predominant IBS.<\/jats:p><jats:p>OBJECTIVE: In the present study, 5-HT synthesis was measured using positron emission tomography, with \u03b1-[<jats:sup>11<\/jats:sup>C]methyl-l-tryptophan as the tracer, in patients with IBS. The aim of the present study was to compare 5-HT synthesis in the IBS patients with that in the controls, and to compare 5-HT synthesis between male and female IBS patients.<\/jats:p><jats:p>METHODS: Six male and six female nonconstipated IBS patients were scanned. Age-matched healthy volunteers were scanned as controls. Eighty minute dynamic scans were performed. Functional 5-HT synthesis images were analyzed using statistical parametric mapping.<\/jats:p><jats:p>RESULTS: 5-HT synthesis was greater only in the female IBS patients in the right medial temporal gyrus (multimodal sensory association cortex) compared with the female controls (P&lt;0.001).<\/jats:p><jats:p>CONCLUSIONS: The greater brain 5-HT synthesis in the female IBS patients than in the controls may be related to the pathological visceral pain processing of the IBS patients, a larger female predominance of the disorder, and the sex difference of the efficacy of the 5-HT<jats:sub>3<\/jats:sub>antagonist in treatment.<\/jats:p>","DOI":"10.1155\/2003\/572127","type":"journal-article","created":{"date-parts":[[2016,3,20]],"date-time":"2016-03-20T21:01:37Z","timestamp":1458507697000},"page":"191-196","source":"Crossref","is-referenced-by-count":41,"title":["Sex Differences of Brain Serotonin Synthesis in Patients with Irritable Bowel Syndrome Using \u03b1-[<sup>11<\/sup>C]methyl-L-tryptophan, Positron Emission Tomography and Statistical Parametric Mapping"],"prefix":"10.1155","volume":"17","author":[{"given":"Akio","family":"Nakai","sequence":"first","affiliation":[{"name":"Montreal Neurological Institute, McGill University, Montreal, Canada"},{"name":"Permanent address, Department of Pediatrics, Fukui Medical University School of Medicine, Fukui, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikata","family":"Kumakura","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute, McGill University, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Boivin","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de l\u2019Universite de Montreal, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Rosa","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute, McGill University, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirko","family":"Diksic","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute, McGill University, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Glaxo Wellcome Inc, Mississauga, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Kersey","sequence":"additional","affiliation":[{"name":"Glaxo Wellcome Inc, Mississauga, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2003\/572127.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2003\/572127.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T12:36:22Z","timestamp":1471955782000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2003\/572127\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003]]}},"alternative-id":["572127"],"URL":"https:\/\/doi.org\/10.1155\/2003\/572127","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2003]]}}}