{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:23:19Z","timestamp":1777555399246,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"2-3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RR01192"],"award-info":[{"award-number":["RR01192"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20-CA86182"],"award-info":[{"award-number":["P20-CA86182"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RR01192"],"award-info":[{"award-number":["RR01192"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20-CA86182"],"award-info":[{"award-number":["P20-CA86182"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004802","name":"California Breast Cancer Research Program","doi-asserted-by":"publisher","award":["RR01192"],"award-info":[{"award-number":["RR01192"]}],"id":[{"id":"10.13039\/100004802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004802","name":"California Breast Cancer Research Program","doi-asserted-by":"publisher","award":["P20-CA86182"],"award-info":[{"award-number":["P20-CA86182"]}],"id":[{"id":"10.13039\/100004802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000142","name":"Avon Foundation for Women","doi-asserted-by":"publisher","award":["RR01192"],"award-info":[{"award-number":["RR01192"]}],"id":[{"id":"10.13039\/100000142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000142","name":"Avon Foundation for Women","doi-asserted-by":"publisher","award":["P20-CA86182"],"award-info":[{"award-number":["P20-CA86182"]}],"id":[{"id":"10.13039\/100000142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009819","name":"Chao Family Comprehensive Cancer Center","doi-asserted-by":"crossref","award":["RR01192"],"award-info":[{"award-number":["RR01192"]}],"id":[{"id":"10.13039\/100009819","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009819","name":"Chao Family Comprehensive Cancer Center","doi-asserted-by":"crossref","award":["P20-CA86182"],"award-info":[{"award-number":["P20-CA86182"]}],"id":[{"id":"10.13039\/100009819","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>Diffuse optical spectroscopy (DOS) of breast tissue provides quantitative, functional information based on optical absorption and scattering properties that cannot be obtained with other radiographic methods. DOS\u2010measured absorption spectra are used to determine the tissue concentrations of deoxyhemoglobin (Hb\u2010R), oxyhemoglobin (Hb\u2010O<jats:sub>2<\/jats:sub>), lipid, and water (H<jats:sub>2<\/jats:sub>O), as well as to provide an index of tissue hemoglobin oxygen saturation (S<jats:sub>t<\/jats:sub>O<jats:sub>2<\/jats:sub>). Tissue\u2010scattering spectra provide insight into epithelial, collagen, and lipid contributions to breast density. Clinical studies of women with malignant tumors show that DOS is sensitive to processes such as increased tissue vascularization, hypoxia, and edema. In studies of healthy women, DOS detects variations in breast physiology associated with menopausal status, menstrual cycle changes, and hormone replacement. Current research involves using DOS to monitor tumor response to therapy and the co\u2010registration of DOS with magnetic resonance imaging. By correlating DOS\u2010derived parameters with lesion pathology and specific molecular markers, we anticipate that composite \u201ctissue optical indices\u201d can be developed that non\u2010invasively characterize both tumor and normal breast\u2010tissue function.<\/jats:p>","DOI":"10.1155\/2004\/460797","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T11:29:40Z","timestamp":1371122980000},"page":"95-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["The Role of Diffuse Optical Spectroscopy in the Clinical Management of Breast Cancer"],"prefix":"10.1155","volume":"19","author":[{"given":"Natasha","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert E.","family":"Cerussi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Jakubowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hsiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce J.","family":"Tromberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,12]]},"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2004\/460797.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2004\/460797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:54:46Z","timestamp":1723056886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2004\/460797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":0,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1155\/2004\/460797"],"URL":"https:\/\/doi.org\/10.1155\/2004\/460797","archive":["Portico"],"relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"2004-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}