{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:48:09Z","timestamp":1761562089682},"reference-count":0,"publisher":"Hindawi Limited","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p><jats:bold>OBJECTIVE:<\/jats:bold>Pancreatic cancer is known to aggregate in some families and has been associated with a wide variety of cancer syndromes. The authors describe their experience with pancreatic cancer and the range of associated cancer syndromes.<\/jats:p><jats:p><jats:bold>METHODS:<\/jats:bold>The charts of all patients seen for concern of a hereditary cancer syndrome in the Cancer Genetics Clinic at the University of Alberta between 1995 and 2002 were reviewed.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold>Forty families reported a personal or family history of pancreatic cancer in the context of a possible hereditary cancer syndrome. Three additional families reported a history of pancreatitis. Twenty-four (56%) of those families were suspected of having a hereditary breast and ovarian cancer syndrome. A further seven (16%) were suspected of having hereditary nonpolyposis colon cancer. Only three (7%) were believed to be at risk for a site-specific pancreatic cancer syndrome. Another three (7%) were suspicious for hereditary pancreatitis. The remaining family histories were suggestive of Li-Fraumeni syndrome, von Hippel-Lindau syndrome or a nonspecific cancer predisposition.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold>With such a wide variety of hereditary cancer syndromes associated with pancreatic cancer, an accurate assessment of the family history is essential to determine the most appropriate cancer screening for at-risk family members and to guide any molecular testing that may be offered.<\/jats:p>","DOI":"10.1155\/2004\/631909","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T21:00:44Z","timestamp":1458766844000},"page":"17-21","source":"Crossref","is-referenced-by-count":12,"title":["The Hereditary Spectrum of Pancreatic Cancer: The Edmonton Experience"],"prefix":"10.1155","volume":"18","author":[{"given":"Margaret","family":"Lilley","sequence":"first","affiliation":[{"name":"Alberta Cancer Genetics Program, Walter C Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawna","family":"Gilchrist","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Genetics, Walter C Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2004\/631909.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2004\/631909.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T11:26:01Z","timestamp":1471951561000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2004\/631909\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004]]}},"alternative-id":["631909"],"URL":"https:\/\/doi.org\/10.1155\/2004\/631909","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2004]]}}}