{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:27:36Z","timestamp":1791012456668,"version":"4.1.0"},"reference-count":0,"publisher":"Hindawi Limited","issue":"11","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>The standard 3 h breath hydrogen (3hBH<jats:sub>2<\/jats:sub>) test distinguishes lactose maldigesters from lactose digesters. However, multiple factors impact on BH<jats:sub>2<\/jats:sub>and care is needed to exclude a priori variables. When these factors are controlled, a negative BH<jats:sub>2<\/jats:sub>test implies lactase persistent status or lactase nonpersistent status with colonic adaptation. A case of a Sicilian man who tested negative (lactase persistent status confirmed) on an initial 50 g lactose challenge is described. It was observed that he consumed 28.1 g lactose\/day before testing. He subsequently underwent five additional challenge tests in the course of the next 10 months. In four tests the dose intake of lactose was varied upon instruction, and in the fifth test a 30 g lactulose challenge was carried out. It was demonstrated that on radically decreasing lactose intake, a full lactase nonpersistent status was unmasked. Output of 3hBH<jats:sub>2<\/jats:sub>varied inversely with daily lactose intake. Finally, at a time when he was readapted to lactose, there was no discernible adaptation to lactulose challenge. It was concluded that 'occult' colonically adapted subjects may contribute to negative BH<jats:sub>2<\/jats:sub>tests. There is a relationship between variation in lactose intake and the results of BH<jats:sub>2<\/jats:sub>testing. Finally, there was no cross-adaptation to lactulose challenge when lactose was used as the adapting sugar.<\/jats:p>","DOI":"10.1155\/2004\/763529","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T21:00:46Z","timestamp":1458766846000},"page":"677-680","source":"Crossref","is-referenced-by-count":11,"title":["Deadaption and Readaptation with Lactose, But No Cross-Adaptation to Lactulose: A Case of Occult Colonic Bacterial Adaptation"],"prefix":"10.1155","volume":"18","author":[{"given":"Andrew","family":"Szilagyi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, School of Medicine, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, School of Medicine, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Vinokuroff","sequence":"additional","affiliation":[{"name":"Departmentt of Dietetics, Sir Mortimer B Davis Jewish General Hospital, McGill University, School of Medicine, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darakhshan","family":"Ahman","sequence":"additional","affiliation":[{"name":"Institut national de la recherch\u00e9 scientique \u2014 Institut Armand Frappier, Centre de microbiologie et biotechnologie, Universit\u00e9 du Qu\u00e9bec, Pointe\u2013Claire, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Nathwani","sequence":"additional","affiliation":[{"name":"Departmentt of Dietetics, Sir Mortimer B Davis Jewish General Hospital, McGill University, School of Medicine, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samara","family":"Yesovitch","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, School of Medicine, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2004\/763529.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2004\/763529.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T14:18:37Z","timestamp":1471961917000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2004\/763529\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004]]}},"alternative-id":["763529"],"URL":"https:\/\/doi.org\/10.1155\/2004\/763529","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2004]]}}}