{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:15:32Z","timestamp":1777662932509,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000019","name":"Crohn\u2019s and Colitis Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>OBJECTIVE: To determine the utility of the anti-Saccharomyces cerevisiae antibody (ASCA) ELISA test developed in Manitoba in 2001 in a population-wide sample referred from physicians across Manitoba in their investigation of patients with gastrointestinal symptoms.<\/jats:p><jats:p>METHODS: Patients whose serum was referred for ASCA testing in 2001 and 2002 were eligible for the present study. ELISA was performed by a technologist, blind to patient diagnoses. A single investigator contacted physicians to facilitate chart review. Data collected included demographics, final diagnoses and tests used to substantiate the final diagnosis.<\/jats:p><jats:p>RESULTS: Of 482 subjects identified, 410 charts were available for review and 29 of those were unavailable for follow-up or had incomplete charts. The present study population included Crohn's disease (CD, n=114), ulcerative colitis (n=74), indeterminate colitis (n=31), celiac disease (n=9), irritable bowel syndrome (n=75), other diagnoses (n=33) and no disease (n=45). ASCA had a sensitivity of 37% (95% CI 27.8 to 46.8) and specificity of 97% (95% CI 93.8 to 98.6) for diagnosing CD and an odds ratio for a diagnosis of CD of 18.4 (95% CI 8.2 to 41.3). The 47 ASCA-positive patients included the following diagnoses: CD=39, ulcerative colitis=3, indeterminate colitis=1, celiac disease=3 and no disease=1. The likelihood of having an inflammatory disease if ASCA is positive was nearly 40-fold.<\/jats:p><jats:p>CONCLUSION: A positive ASCA test using this assay nearly clinches a diagnosis of some form of inflammatory intestinal disease, which is highly likely to be CD. In symptomatic patients, a positive ASCA test should encourage the clinician to pursue further investigations<\/jats:p>","DOI":"10.1155\/2005\/147681","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T18:39:47Z","timestamp":1458585587000},"page":"717-721","source":"Crossref","is-referenced-by-count":16,"title":["The Anti-Saccharomyces Cerevisiae Antibody Assay in a Province-Wide Practice: Accurate in Identifying Cases of Crohn\u2019s Disease and Predicting Inflammatory Disease"],"prefix":"10.1155","volume":"19","author":[{"given":"Brinderjit","family":"Kaila","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Orr","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Manitoba and the Saint Boniface General Hospital Immunology Laboratory, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles N","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Manitoba, Canada"},{"name":"University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2005\/147681.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2005\/147681.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T17:01:27Z","timestamp":1473094887000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2005\/147681\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005]]}},"alternative-id":["147681"],"URL":"https:\/\/doi.org\/10.1155\/2005\/147681","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2005]]}}}