{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:01:46Z","timestamp":1768284106553,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p><jats:italic>Background and Aims<\/jats:italic>: Oncogenes and tumor suppressor genes expression are well described in bladder cancer associated with schistosomiasis especially in Egypt. Scarce studies were directed to colorectal cancer (CRC) associated with <jats:italic>Schistosoma mansoni<\/jats:italic> (<jats:italic>S. mansoni<\/jats:italic>). Apoptosis (programmed cell death) and the genes regulating this process (e.g., Bcl\u20102) have recently become a focus of interest in the study of cancer development and progression. In the present study, we aimed to investigate the expression pattern of p53, Bcl\u20102 and C\u2010Myc in CRC tissues obtained from Egyptian colorectal cancer patients divided in two different groups, one associated with <jats:italic>Schistosoma mansoni<\/jats:italic> (CRC\u2010Sm) and the other without <jats:italic>Schistosoma mansoni<\/jats:italic> (CRC\u2010NSm). <jats:italic>Methods<\/jats:italic>: Seventy\u2010five CRC tumors containing 36 draining lymph node metastatic tumors were immunohistochemically stained using specific monoclonal antibodies for p53, Bcl\u20102 and C\u2010Myc, in addition the apoptotic activity of these tumors were analyzed. <jats:italic>Results and Conclusions<\/jats:italic>: Regardless of the <jats:italic>S. mansoni<\/jats:italic> infection, the obtained Results showed that the apoptotic activity was more evident in p53 diffuse positive tumors (<jats:italic>P<\/jats:italic>=0.021). There was a significant correlation between p53 diffuse positive staining and Bcl\u20102 positive immunostaining (<jats:italic>P<\/jats:italic>=0.011). Signet ring cell carcinoma and mucinous adenocarcinoma exhibited both intense C\u2010Myc expression than non\u2010mucinous carcinoma (<jats:italic>P<\/jats:italic>=0.001). When adjusting for S. mansoni infection, 58.3% of CRC\u2010Sm cases were Bcl\u20102 positive compared to only (33.3%) of CRC\u2010NSm (<jats:italic>P<\/jats:italic>=0.046). Apoptotic activity was more evident in the latter group than of CRC\u2010Sm tumors (<jats:italic>P<\/jats:italic>=0.009). p53 and C\u2010Myc expressions were found insignificantly different in CRC\u2010Sm compared with CRC\u2010NSm (<jats:italic>P<\/jats:italic>&gt;0.05). These observations suggest that the genotoxic agents produced endogenously through the course of <jats:italic>schistosomiasis mansoni<\/jats:italic> may play a role in CRC\u2010Sm pathogenesis through the dysregulation of apoptosis by alteration the expression pattern of Bcl\u20102 protein differently from CRC\u2010NSm suggesting a different biological behavior.<\/jats:p>","DOI":"10.1155\/2005\/547010","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T16:56:07Z","timestamp":1611248167000},"page":"245-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["p53, Bcl\u20102 and C\u2010Myc Expressions in Colorectal Carcinoma Associated with Schistosomiasis in Egypt"],"prefix":"10.1155","volume":"27","author":[{"given":"Khaled R.","family":"Zalata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesam A.","family":"Nasif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Chun","family":"Ming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Lotfy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia A.","family":"Nada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil Gad","family":"El-Hak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen H.","family":"Leech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1]]},"container-title":["Analytical Cellular Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/acp\/2005\/547010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2005\/547010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T12:50:13Z","timestamp":1722343813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2005\/547010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1155\/2005\/547010"],"URL":"https:\/\/doi.org\/10.1155\/2005\/547010","archive":["Portico"],"relation":{},"ISSN":["2210-7177","2210-7185"],"issn-type":[{"value":"2210-7177","type":"print"},{"value":"2210-7185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2005-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}