{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:15Z","timestamp":1787017695831,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"University of Rome","award":["C26F022871"],"award-info":[{"award-number":["C26F022871"]}]},{"name":"University of Rome","award":["RF2003"],"award-info":[{"award-number":["RF2003"]}]},{"name":"Italian Ministry of the University and Scientific Research","award":["C26F022871"],"award-info":[{"award-number":["C26F022871"]}]},{"name":"Italian Ministry of the University and Scientific Research","award":["RF2003"],"award-info":[{"award-number":["RF2003"]}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["C26F022871"],"award-info":[{"award-number":["C26F022871"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF2003"],"award-info":[{"award-number":["RF2003"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>\n                    Among the putative candidate genes for insulin resistance, the peroxisome proliferator\u2010activated receptor \u03b3 coactivator\u20101\u03b1 (PGC\u20101\u03b1) is a transcriptional coactivator of PPAR\u03b3 and \u03b1, regulating a wide range of processes involved in energy production and utilization, such as thermogenesis, liver gluconeogenesis, glucose uptake in muscle. In population studies a Gly482Ser substitution in PGC\u20101\u03b1 has been reported to be associated with increased risk of type diabetes 2 and insulin resistance. In the present study we have analysed the association between the Gly482Ser missense mutation of the PGC\u20101\u03b1 gene and insulin sensitivity and glucose tolerance in a population of obese non\u2010diabetic subjects. The Gly482Ser SNPs was detected by PCR\u2010RFLP in a cohort of 358 Caucasian obese subjects (223 with normal glucose tolerance (NGT) and 125 with impaired glucose tolerance (IGT). We observed a significant association (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.007) between carriers of the Gly482Ser variant of the PGC\u20101\u03b1 gene and insulin resistance measured by HOMA\n                    <jats:sub>IR<\/jats:sub>\n                    . Multivariate analysis confirmed that the Gly482Ser SNP was a significant (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.02) determinant of decreased insulin sensitivity, independently from other well\u2010known modulators of insulin action. In conclusion, we have found significant association between the Gly482Ser variant of the PGC\u20101\u03b1 gene and reduced insulin sensitivity in obese subjects. This association resulted independent from all other known modulators of insulin resistance, and suggests a primary role for the PGC\u20101\u03b1 gene on the genetic susceptibility to insulin resistance in obesity.\n                  <\/jats:p>","DOI":"10.1155\/2005\/576748","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T07:33:16Z","timestamp":1371108796000},"page":"175-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The\n                    <i>Gly482Ser<\/i>\n                    Missense Mutation of the\n                    <i>Peroxisome Proliferator-Activated Receptor \u03b3 Coactivator<\/i>\n                    \u20101\u03b1 (\n                    <i>PGC<\/i>\n                    \u20101\u03b1) Gene Associates with Reduced Insulin Sensitivity in Normal and Glucose\u2010Intolerant Obese Subjects"],"prefix":"10.1155","volume":"21","author":[{"given":"Marzia","family":"Fanelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sentinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Romeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Fallarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Buzzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frida","family":"Leonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Giorgio","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,9]]},"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2005\/576748.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2005\/576748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T17:21:12Z","timestamp":1723051272000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2005\/576748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1155\/2005\/576748"],"URL":"https:\/\/doi.org\/10.1155\/2005\/576748","archive":["Portico"],"relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2006-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}