{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T02:37:47Z","timestamp":1776566267260,"version":"3.51.2"},"reference-count":0,"publisher":"Hindawi Limited","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>BACKGROUND AND AIM: Peptic ulcer disease (PUD) affects 10% of the world population.<jats:italic>Helicobacter pylori<\/jats:italic>infection and the use of a nonsteroidal anti-inflammatory drug (NSAID) are the principal factors associated with PUD. The aim of the present study was to evaluate a cohort of patients with PUD and determine the association between<jats:italic>H pylori<\/jats:italic>infection and NSAID use.<\/jats:p><jats:p>PATIENTS AND METHODS: The medical charts of patients with endoscopic diagnosis of PUD were retrospectively reviewed from September 2002 to August 2003. Patients were divided into three groups according to ulcer etiology:<jats:italic>H pylori<\/jats:italic>infection (group 1); NSAID use (group 2); and combined<jats:italic>H pylori<\/jats:italic>infection and NSAID use (group 3).<\/jats:p><jats:p>RESULTS: One hundred two patients were evaluated: 36 men (35.3%) and 66 women (64.7%). Forty patients had<jats:italic>H pylori<\/jats:italic>infection, 43 had used NSAIDs and 15 had combined<jats:italic>H pylori<\/jats:italic>infection and NSAID use; four patients with ulcers secondary to malignancy were excluded. The frequency of women was significantly higher in group 2 (P=0.01). The mean age of patients in group 1 was significantly lower than in the other two groups (P=0.003). PUD developed earlier in group 3 than in group 2 (5.0\u00b14.7 months versus 1.4\u00b12.1 months, respectively, P=0.018). Thirty-two patients (32.7%) had bleeding peptic ulcer. Group 2 had a higher risk of bleeding peptic ulcer than the other two groups (P=0.001).<\/jats:p><jats:p>CONCLUSIONS: The development of PUD was observed earlier in the combined<jats:italic>H pylori<\/jats:italic>and NSAID group than in patients with only NSAID use. This suggests a synergic effect between the two risks factors in the development of PUD.<\/jats:p>","DOI":"10.1155\/2006\/175217","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T07:50:44Z","timestamp":1458028244000},"page":"277-280","source":"Crossref","is-referenced-by-count":48,"title":["The Association of<i>Helicobacter pylori<\/i>Infection and Nonsteroidal Anti-Inflammatory Drugs in Peptic Ulcer Disease"],"prefix":"10.1155","volume":"20","author":[{"given":"Juan Carlos","family":"Zapata-Colindres","sequence":"first","affiliation":[{"name":"Departments of Gastroenterology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Zepeda-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Endoscopy, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Monta\u00f1o-Loza","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"V\u00e1zquez-Ballesteros","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"de Jes\u00fas Villalobos","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Valdovinos-Andraca","sequence":"additional","affiliation":[{"name":"Endoscopy, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2006\/175217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2006\/175217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T07:51:06Z","timestamp":1471938666000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2006\/175217\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006]]}},"alternative-id":["175217"],"URL":"https:\/\/doi.org\/10.1155\/2006\/175217","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]}}}