{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:03:07Z","timestamp":1740171787629,"version":"3.37.3"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2006,1]]},"abstract":"Objective<\/jats:italic>: To determine the \u03b2<\/jats:italic>\u2010amyloid precursor protein (\u03b2<\/jats:italic>APP) isoforms ratio as a risk factor for Alzheimer\u2019s Disease and to assess its relationship with demographic and genetic variables of the disease.<\/jats:p>Methods<\/jats:italic>: Blood samples from 26 patients fulfilling NINCDS\u2010ADRDA diagnostic criteria for AD and 46 healthy control subjects were collected for Western blotting for \u03b2<\/jats:italic>APP. A ratio of \u03b2<\/jats:italic>APP isoforms, in optical densities, between the upper band (130 Kd) and the lower bands (106\u2013110 Kd) was obtained. Odds ratios were obtained to determine risk factor of this component.<\/jats:p>Results<\/jats:italic>: \u03b2<\/jats:italic>APP ratio on AD subjects was lower than that of control subjects: 0.3662 \u00b1 0.1891 vs. 0.6769 \u00b1 0.1021 (mean \u00b1 SD, p<0.05). A low \u03b2<\/jats:italic>APP ratio (<0.6) showed an OR of 4.63 (95% CI 1.45 \u00b1 15.33). When onset of disease was taken into account, a \u03b2<\/jats:italic>APP ratio on EOAD subjects of 0.3965 \u00b1 0.1916 was found vs. 0.3445 \u00b1 0.1965 on LOAD subjects (p>0.05).<\/jats:p>Conclusions<\/jats:italic>: Altered \u03b2<\/jats:italic>APP isoforms is a high risk factor for Alzheimer\u2019s disease, although it has no influence on the time of onset of the disease.<\/jats:p>","DOI":"10.1155\/2006\/347502","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T11:33:36Z","timestamp":1371123216000},"page":"119-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Altered \u03b2<\/i>\u2010Amyloid Precursor Protein Isoforms in Mexican Alzheimer\u2019s Disease Patients"],"prefix":"10.1155","volume":"22","author":[{"given":"V. J.","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. G.","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Gallegos-Arreola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Mac\u00edas-Islas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. D.","family":"Arias-Merino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Loera-Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mart\u00ednez-Cano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. E.","family":"Vel\u00e1zquez-Brizuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Rosales-Corral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Curiel-Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pacheco-Mois\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,9]]},"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2006\/347502.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2006\/347502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:06:35Z","timestamp":1723057595000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2006\/347502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1155\/2006\/347502"],"URL":"https:\/\/doi.org\/10.1155\/2006\/347502","archive":["Portico"],"relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"type":"print","value":"0278-0240"},{"type":"electronic","value":"1875-8630"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2006-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}