{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:47:34Z","timestamp":1769600854385,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry of Health of the Hungarian Republic","award":["ETT-130\/2003-041\/037"],"award-info":[{"award-number":["ETT-130\/2003-041\/037"]}]},{"name":"Ministry of Health of the Hungarian Republic","award":["OTKA-037883"],"award-info":[{"award-number":["OTKA-037883"]}]},{"name":"Hungarian Research Foundation","award":["ETT-130\/2003-041\/037"],"award-info":[{"award-number":["ETT-130\/2003-041\/037"]}]},{"name":"Hungarian Research Foundation","award":["OTKA-037883"],"award-info":[{"award-number":["OTKA-037883"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic> Soluble CD40 ligand (sCD40L) has been suggested as a key mediator between inflammation and atherosclerosis, and the CD40\u2010CD40L interaction has a role in atherosclerotic lesion progression. We evaluated if platelet released serum sCD40L and sCD40 levels differ between patients with early onset occlusive carotid artery disease and age\u2010matched controls.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> sCD40L and sCD40 levels were measured in serum samples of 60 patients with occlusive carotid artery disease and 30 age\u2010matched controls using ELISA. Degree of stenosis of the internal carotid artery (ICA), and intima\u2010media thickness (IMT) in the common carotid artery were measured by high resolution ultrasound. Values are given as mean \u00b1 SD.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Mean age was 50.9 \u00b1 3.5 and 50.1 \u00b1 3.5 years in the patient and control groups. IMT was significantly thicker in patients than in controls (0.89 \u00b1 0.14 vs. 0.78 \u00b10.12 mm, <jats:italic>p<\/jats:italic> = 0.0003). Serum levels of sCD40L were significantly higher (6.9 \u00b1 5 vs. 4.5 \u00b1 3.0 ng\/mL, <jats:italic>p<\/jats:italic> = 0.038) in patients, whereas sCD40 did not differ significantly between patients and controls (85 \u00b1 56.9 vs. 79.3 \u00b1 18.7 pg\/mL, <jats:italic>p<\/jats:italic> = 0.34). IMT did not correlate with sCD40L or sCD40 levels (<jats:italic>R<\/jats:italic> = \u22120.03, <jats:italic>p<\/jats:italic> = 0.77; and <jats:italic>R<\/jats:italic> = 0.109, <jats:italic>p<\/jats:italic> = 0.308, respectively).<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> sCD40L but not sCD40 levels are significantly higher in patients with occlusive carotid artery disease. Platelet derived sCD40L may be a key mediator among inflammation, thrombosis and atherosclerosis.<\/jats:p>","DOI":"10.1155\/2006\/427174","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T11:33:36Z","timestamp":1371123216000},"page":"133-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Serum Levels of Platelet Released CD40 Ligand Are Increased in Early Onset Occlusive Carotid Artery Disease"],"prefix":"10.1155","volume":"22","author":[{"given":"J\u00f3zsef","family":"Balla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ria T\u00fcnde","family":"Magyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1niel","family":"Bereczki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Valikovics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Em\u00f6ke","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Barna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"P\u00e1l","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Balla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Csiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Blask\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,9]]},"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2006\/427174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2006\/427174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:06:38Z","timestamp":1723057598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2006\/427174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1155\/2006\/427174"],"URL":"https:\/\/doi.org\/10.1155\/2006\/427174","archive":["Portico"],"relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2006-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}