{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:39:40Z","timestamp":1760132380114},"reference-count":0,"publisher":"Hindawi Limited","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>BACKGROUND: Many people living with chronic viral hepatitis C (HCV) report reduced health-related quality of life. The relative contribution of behavioural, psychosocial and HCV disease factors to reduction in HCV health-related quality of life is not well understood. The objectives of the present study were to compare standardized health-related quality of life scores between Canadian HCV patients and age-matched Canadian and American norms, and to examine the relative contribution of biopsychosocial variables (ie, cigarette smoking, alcohol intake and depression) to health-related quality of life scores among Canadian HCV patients.<\/jats:p><jats:p>METHODS: HCV RNA-positive patients were recruited during their first visit to the Ottawa Hospital Viral Hepatitis Clinic (Ottawa, Ontario). A questionnaire assessing health behaviours, health-related quality of life and depressed mood was completed. Data on liver studies, liver biopsy findings and HIV serostatus were also collected.<\/jats:p><jats:p>RESULTS: A total of 123 participants (71% men) ranging from 20 to 67 years of age were evaluated. All had compensated liver function. Patients reported significantly lower health-related quality of life compared with age-matched Canadian and American normative samples. In a series of hierarchical multiple regression models, depression and smoking were independently related to compromised health-related quality of life scores, even after controlling for sociodemographic variables and health behaviours.<\/jats:p><jats:p>DISCUSSION: These results highlight the value of adopting a biopsychosocial model of HCV care. Depressed mood and smoking behaviour should be evaluated in HCV patients. Empirically validated psychological and pharmacological treatments for depression and smoking cessation may improve health-related quality of life in HCV infected patients.<\/jats:p>","DOI":"10.1155\/2006\/469761","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T07:57:30Z","timestamp":1458028650000},"page":"81-86","source":"Crossref","is-referenced-by-count":18,"title":["Depression and Cigarette Smoking Independently Relate to Reduced Health-Related Quality of Life among Canadians Living with Hepatitis C"],"prefix":"10.1155","volume":"20","author":[{"given":"Louise","family":"Balfour","sequence":"first","affiliation":[{"name":"The Ottawa Hospital Division of Infectious Diseases Viral Hepatitis Program, Ottawa, Ontario, Canada"},{"name":"University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Ottawa Health Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis","family":"Cooper","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Division of Infectious Diseases Viral Hepatitis Program, Ottawa, Ontario, Canada"},{"name":"University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Ottawa Health Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kowal","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Division of Infectious Diseases Viral Hepatitis Program, Ottawa, Ontario, Canada"},{"name":"University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio A","family":"Tasca","sequence":"additional","affiliation":[{"name":"University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Ottawa Health Research Institute, Ottawa, Ontario, Canada"},{"name":"Carleton University, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Silverman","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Division of Infectious Diseases Viral Hepatitis Program, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Kane","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Division of Infectious Diseases Viral Hepatitis Program, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Garber","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Division of Infectious Diseases Viral Hepatitis Program, Ottawa, Ontario, Canada"},{"name":"University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Ottawa Health Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2006\/469761.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2006\/469761.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T09:33:50Z","timestamp":1471944830000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2006\/469761\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006]]}},"alternative-id":["469761"],"URL":"https:\/\/doi.org\/10.1155\/2006\/469761","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]}}}