{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:07:47Z","timestamp":1790460467185,"version":"4.1.0"},"reference-count":0,"publisher":"Hindawi Limited","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>INTRODUCTION: The effectiveness of polyethylene glycol solutions (PEG) for colon cleansing is often limited by the inability of patients to drink adequate portions of the 4 L solution. The aim of the present study was to determine whether a reduced volume of PEG combined with stimulant laxatives would be better tolerated and as or more effective than the standard dose.<\/jats:p><jats:p>METHODS: Patients undergoing outpatient colonoscopy were randomly assigned to receive either low-volume PEG plus sennosides (120 mg oral sennosides syrup followed by 2 L PEG) or the standard volume preparation (4 L PEG). The subjects rated the tolerability of the preparations and their symptoms. Colonoscopists were blind to the colonic cleansing preparation and graded the cleansing efficacy using a validated tool (the Ottawa scale).<\/jats:p><jats:p>RESULTS: The low-volume PEG plus sennosides preparation was significantly better tolerated than the standard large volume PEG (P&lt;0.001) but was less efficacious (P=0.03). Thirty-eight per cent of patients in the large volume PEG group were unable to finish the preparation, compared with only 6% in the reduced volume group. There were no adverse events reported.<\/jats:p><jats:p>CONCLUSIONS: Although the low-volume PEG plus sennosides preparation was better tolerated, it was not as effective as standard large-volume PEG. However, in view of the significant difference in tolerance, further research investigating possible improvements in the reduced-volume regimen seems warranted.<\/jats:p>","DOI":"10.1155\/2006\/621367","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T08:01:13Z","timestamp":1458028873000},"page":"101-105","source":"Crossref","is-referenced-by-count":42,"title":["Combined Low-Volume Polyethylene Glycol Solution Plus Stimulant Laxatives versus Standard-Volume Polyethylene Glycol Solution: A Prospective, Randomized Study of Colon Cleansing before Colonoscopy"],"prefix":"10.1155","volume":"20","author":[{"given":"Lawrence C","family":"Hookey","sequence":"first","affiliation":[{"name":"Gastrointestinal Diseases Research Unit, Queens University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T","family":"Depew","sequence":"additional","affiliation":[{"name":"Gastrointestinal Diseases Research Unit, Queens University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"Vanner","sequence":"additional","affiliation":[{"name":"Gastrointestinal Diseases Research Unit, Queens University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2006\/621367.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2006\/621367.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T10:10:04Z","timestamp":1471947004000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2006\/621367\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006]]}},"alternative-id":["621367"],"URL":"https:\/\/doi.org\/10.1155\/2006\/621367","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]}}}